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Tbio
TXLNG
Gamma-taxilin

Protein Summary
Description
May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression. This gene encodes a member of the taxilin family. The encoded protein binds to the C-terminal coiled-coil region of syntaxin family members 1A, 3A and 4A, and may play a role in intracellular vesicle trafficking. This gene is up-regulated by lipopolysaccharide and the gene product may be involved in cell cycle regulation. The related mouse protein was also shown to inhibit activating transcription factor 4-mediated transcription and thus regulate bone mass accrual. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380122
  • ENSP00000369465
  • ENSG00000086712
  • ENST00000398155
  • ENSP00000381222

Symbol
  • CXorf15
  • ELRG
  • LSR5
  • ELRG
  • FIAT
  • LSR5
  • TXLNGX
  • CXorf15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
histone modification site profile
0.81
transcription factor binding site profile
0.76
interacting protein
0.72
microRNA
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.43   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.43   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
5
3
5
81.9
prostate specific antigen measurement
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
5
81.9
prostate specific antigen measurement
1
57.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
taxilin gamma
738047
Macaque
taxilin gamma
713769
Mouse
MGI:3590652
353170
Rat
RGD:1564371
302680
Dog
taxilin gamma
VGNC:48008
480853
Species
Name
OMA
EggNOG
Inparanoid
Chimp
taxilin gamma
Macaque
taxilin gamma
Mouse
Rat
Dog
taxilin gamma
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NUQ3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Name
Explore in Pharos
Explore in Source
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (79)
1 – 10 of 79
TXLNB
Tbio
Novelty:  0.12751933
p_int:  0.999999989
p_ni:  1.1e-8
Score:  0.866
Data Source:  BioPlex,STRINGDB
TXLNA
Tbio
Novelty:  0.02549959
p_int:  0.999999394
p_ni:  6.06e-7
Score:  0.879
Data Source:  BioPlex,STRINGDB
TCL1A
Tbio
Novelty:  0.00606987
p_int:  0.999998951
p_ni:  0.000001049
Data Source:  BioPlex
HIF1AN
Tbio
Novelty:  0.00861018
p_int:  0.99997851
p_ni:  0.00002149
Data Source:  BioPlex
CPNE2
Tdark
Novelty:  0.24188419
p_int:  0.999961283
p_ni:  0.000038717
Data Source:  BioPlex
ENTHD1
Tdark
Novelty:  5.29427978
p_int:  0.999905163
p_ni:  0.000094837
Data Source:  BioPlex
KIF2B
Tbio
Novelty:  0.09958244
p_int:  0.999802308
p_ni:  0.000197691
Score:  0.158
Data Source:  BioPlex,STRINGDB
RGS20
Tbio
Novelty:  0.04087618
p_int:  0.999370026
p_ni:  0.000629974
Data Source:  BioPlex
MIS18A
Tbio
Novelty:  0.08143008
p_int:  0.999047942
p_ni:  0.000952058
Score:  0.16
Data Source:  BioPlex,STRINGDB
TRIM44
Tbio
Novelty:  0.00483553
p_int:  0.9981383
p_ni:  0.0018617
Data Source:  BioPlex
Publication Statistics
PubMed Score  15.43

PubMed score by year
PubTator Score  40.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer