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Tbio
AGPAT5
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

Protein Summary
Description
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward lysophosphatidylglycerol not detectable. This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. A pseudogene of this gene is present on the Y chromosome. [provided by RefSeq, Aug 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285518
  • ENSP00000285518
  • ENSG00000155189
  • ENST00000646327
  • ENSP00000495562
  • ENSG00000284980

Symbol
  • LPAATE
  • 1AGPAT5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
transcription factor binding site profile
0.95
histone modification site profile
0.88
microRNA
0.82
kinase perturbation
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.05   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.05   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
55.6
low density lipoprotein cholesterol measurement
1
1
1
55.6
total cholesterol measurement
1
1
1
53.2
total cholesterol measurement
1
1
1
53.2
high density lipoprotein cholesterol measurement
1
1
1
27.7
Items per page:
1 – 5 of 7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
55.6
low density lipoprotein cholesterol measurement
1
55.6
total cholesterol measurement
1
53.2
total cholesterol measurement
1
53.2
high density lipoprotein cholesterol measurement
1
27.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
1-acylglycerol-3-phosphate O-acyltransferase 5
VGNC:3034
463969
Macaque
1-acylglycerol-3-phosphate O-acyltransferase 5
716847
Mouse
MGI:1196345
52123
Rat
RGD:1306405
306582
Dog
1-acylglycerol-3-phosphate O-acyltransferase 5
VGNC:49767
100684122
Species
Name
OMA
EggNOG
Inparanoid
Chimp
1-acylglycerol-3-phosphate O-acyltransferase 5
Macaque
1-acylglycerol-3-phosphate O-acyltransferase 5
Mouse
Rat
Dog
1-acylglycerol-3-phosphate O-acyltransferase 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NUQ2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PA
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PA
Protein-Protein Interactions (93)
1 – 10 of 93
CDH13
Tbio
Novelty: 0.00389516
p_int: 0.999852081
p_ni: 0.000147748
p_wrong: 1.72e-7
Score: 0.189
Data Source: BioPlex,STRINGDB
OSTM1
Tbio
Novelty: 0.03033192
p_int: 0.99569972
p_ni: 0.004293854
p_wrong: 0.000006427
Data Source: BioPlex
LAMP2
Tbio
Novelty: 0.00168009
p_int: 0.931426249
p_ni: 0.064523421
p_wrong: 0.00405033
Score: 0.159
Data Source: BioPlex,STRINGDB
CD70
Tbio
Novelty: 0.00420393
p_int: 0.836030819
p_ni: 0.153932448
p_wrong: 0.010036732
Data Source: BioPlex
TMCO3
Tdark
Novelty: 1.16719823
p_int: 0.811646583
p_ni: 0.17036075
p_wrong: 0.017992666
Score: 0.193
Data Source: BioPlex,STRINGDB
APLNR
Tchem
Family: GPCR
Novelty: 0.00224203
p_int: 0.751172942
p_ni: 0.232150912
p_wrong: 0.016676146
Data Source: BioPlex
GPAT3
Tbio
Family: Enzyme
Novelty: 0.03251979
Score: 0.97
Data Source: STRINGDB
GPAT4
Tbio
Family: Enzyme
Novelty: 0.03409111
Score: 0.969
Data Source: STRINGDB
GPAT2
Tbio
Family: Enzyme
Novelty: 0.03807198
Score: 0.957
Data Source: STRINGDB
GPAM
Tbio
Family: Enzyme
Novelty: 0.00973127
Score: 0.95
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.05

PubMed score by year
PubTator Score  2.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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