Tdark TRMT13 tRNA:m(4)X modification enzyme TRM13 homolog

Protein Summary

Description

tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

Uniprot Accession IDs

• Q9NUP7
• Q5VVL0
• Q9NW65

Gene Name

• TRMT13

Ensembl ID

• ENST00000370141
• ENSP00000359160
• ENSG00000122435
• ENST00000482437
• ENSP00000432616

Symbol

• CCDC76
• CCDC76

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.79
cellular component	0.64
tissue sample	0.64
transcription factor perturbation	0.61
transcription factor binding site profile	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.76   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 39   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.76   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0