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Tbio
PIGV
GPI mannosyltransferase 2

Protein Summary
Description
Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly. This gene encodes a mannosyltransferase enzyme involved in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a complex glycolipid that functions as a membrane anchor for many proteins and plays a role in multiple cellular processes including protein sorting and signal transduction. The encoded protein is localized to the endoplasmic reticulum and transfers the second mannose to the GPI backbone. Mutations in this gene are associated with hyperphosphatasia cognitive disability syndrome. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000078527
  • ENSP00000078527
  • ENSG00000060642
  • ENST00000374145
  • ENSP00000363260

Symbol
  • PIG-V
  • HPMRS1
  • GPI-MT-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
transcription factor
0.83
histone modification site profile
0.78
virus perturbation
0.76
transcription factor perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.26   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.26   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
2
2
90.4
sex hormone-binding globulin measurement
6
1
6
88.2
neutrophil count
3
3
4
87.9
triglyceride measurement
4
2
4
84.7
testosterone measurement
3
1
3
84.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
90.4
sex hormone-binding globulin measurement
6
88.2
neutrophil count
4
87.9
triglyceride measurement
4
84.7
testosterone measurement
3
84.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
phosphatidylinositol glycan anchor biosynthesis class V
714898
Mouse
MGI:2442480
230801
Rat
RGD:1309526
366478
Dog
phosphatidylinositol glycan anchor biosynthesis class V
VGNC:44544
106557463
Horse
phosphatidylinositol glycan anchor biosynthesis class V
VGNC:21436
100057125
Species
Name
OMA
EggNOG
Inparanoid
Macaque
phosphatidylinositol glycan anchor biosynthesis class V
Mouse
Rat
Dog
phosphatidylinositol glycan anchor biosynthesis class V
Horse
phosphatidylinositol glycan anchor biosynthesis class V
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NUD9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of glycosylphosphatidylinositol (GPI)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Synthesis of glycosylphosphatidylinositol (GPI)
Protein-Protein Interactions (84)
1 – 10 of 84
PIGM
Tbio
Family:  Enzyme
Novelty:  0.02186069
Score:  0.992
Data Source:  STRINGDB
PIGB
Tbio
Family:  Enzyme
Novelty:  0.05237713
Score:  0.988
Data Source:  STRINGDB
PIGN
Tbio
Family:  Enzyme
Novelty:  0.02210783
Score:  0.986
Data Source:  STRINGDB
PIGO
Tbio
Family:  Enzyme
Novelty:  0.05949164
Score:  0.947
Data Source:  STRINGDB
DPM2
Tdark
Novelty:  0.04752556
Score:  0.946
Data Source:  STRINGDB
DPM1
Tbio
Family:  Enzyme
Novelty:  0.01317862
Score:  0.937
Data Source:  STRINGDB
DPM3
Tdark
Family:  Enzyme
Novelty:  0.05248147
Score:  0.929
Data Source:  STRINGDB
PIGX
Tdark
Novelty:  1.9278829
Score:  0.929
Data Source:  STRINGDB
PGAP2
Tbio
Novelty:  0.06145169
Score:  0.909
Data Source:  STRINGDB
ALG3
Tbio
Family:  Enzyme
Novelty:  0.0159047
Score:  0.894
Data Source:  STRINGDB
Publication Statistics
PubMed Score  17.26

PubMed score by year
PubTator Score  10.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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