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Tdark
MDN1
Midasin

Protein Summary
Description
Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369393
  • ENSP00000358400
  • ENSG00000112159
  • ENST00000629399
  • ENSP00000486270

Symbol
  • KIAA0301
  • Rea1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
0.93
transcription factor binding site profile
0.83
gene perturbation
0.77
disease perturbation
0.74


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.89   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 12   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.89   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 12   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
midasin AAA ATPase 1
VGNC:3464
462886
Macaque
midasin AAA ATPase 1
703389
Mouse
MGI:1926159
100019
Dog
midasin AAA ATPase 1
VGNC:43108
474995
Horse
midasin AAA ATPase 1
VGNC:20061
100071075
Species
Name
OMA
EggNOG
Inparanoid
Chimp
midasin AAA ATPase 1
Macaque
midasin AAA ATPase 1
Mouse
Dog
midasin AAA ATPase 1
Horse
midasin AAA ATPase 1
Protein Structure (0 Structures, 22 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (195)
1 – 10 of 195
DPEP1
Tclin
Family: Enzyme
Novelty: 0.00384946
p_int: 0.998729154
p_ni: 0.001270846
Data Source: BioPlex
OPALIN
Tdark
Novelty: 0.08221612
p_int: 0.986448552
p_ni: 0.013551448
Data Source: BioPlex
DKKL1
Tbio
Novelty: 0.00544618
p_int: 0.96938417
p_ni: 0.03061583
Data Source: BioPlex
METTL9
Tdark
Family: Enzyme
Novelty: 0.20589257
p_int: 0.946734575
p_ni: 0.053265425
Data Source: BioPlex
GLMP
Tdark
Novelty: 0.10163099
p_int: 0.933367154
p_ni: 0.066632839
p_wrong: 7e-9
Data Source: BioPlex
PARP16
Tbio
Family: Enzyme
Novelty: 0.09651799
p_int: 0.930321296
p_ni: 0.069678704
Score: 0.19
Data Source: BioPlex,STRINGDB
TMEM9
Tbio
Novelty: 0.06916197
p_int: 0.916286467
p_ni: 0.083713533
Data Source: BioPlex
VSIG1
Tbio
Novelty: 0.15442611
p_int: 0.885724231
p_ni: 0.114275767
p_wrong: 2e-9
Data Source: BioPlex
CD70
Tbio
Novelty: 0.00420393
p_int: 0.849871234
p_ni: 0.150128766
Data Source: BioPlex
TGOLN2
Tbio
Novelty: 0.005107
p_int: 0.846393809
p_ni: 0.153606191
Data Source: BioPlex
Publication Statistics
PubMed Score  51.89

PubMed score by year
PubTator Score  14.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer