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Tdark
CATSPERZ
Cation channel sperm-associated protein subunit zeta

Protein Summary
Description
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for a distribution of the CatSper complex in linear quadrilateral nanodomains along the flagellum, maximizing fertilization inside the mammalian female reproductive tract.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328404
  • ENSP00000491717
  • ENSG00000219435

Symbol
  • C11orf20
  • TEX40
  • TEX40
  • C11orf20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.4   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.4   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (52)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
3
6
7
97.1
BMI-adjusted waist-hip ratio
6
6
10
97.1
urate measurement
1
4
4
94.5
triglyceride measurement
4
3
4
93.5
high density lipoprotein cholesterol measurement
5
3
5
92.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
7
97.1
BMI-adjusted waist-hip ratio
10
97.1
urate measurement
4
94.5
triglyceride measurement
4
93.5
high density lipoprotein cholesterol measurement
5
92.1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NTU4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
LIFEdb
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (41)
1 – 10 of 41
CATSPERE
Tdark
Novelty:  0.95910237
Score:  0.864
Data Source:  STRINGDB
CATSPERD
Tdark
Novelty:  0.85066163
Score:  0.863
Data Source:  STRINGDB
CATSPERB
Tdark
Novelty:  0.69373919
Score:  0.84
Data Source:  STRINGDB
CATSPERG
Tdark
Novelty:  0.73161601
Score:  0.826
Data Source:  STRINGDB
CATSPER2
Tchem
Family:  IC
Novelty:  0.03701031
Score:  0.809
Data Source:  STRINGDB
CATSPER1
Tchem
Family:  IC
Novelty:  0.01971564
Score:  0.8
Data Source:  STRINGDB
CACNA1H
Tclin
Family:  IC
Novelty:  0.00342394
Score:  0.734
Data Source:  STRINGDB
CATSPER4
Tchem
Family:  IC
Novelty:  0.4554917
Score:  0.724
Data Source:  STRINGDB
CACNA1D
Tclin
Family:  IC
Novelty:  0.00314752
Score:  0.724
Data Source:  STRINGDB
CACNA1F
Tchem
Family:  IC
Novelty:  0.00431963
Score:  0.724
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2.40

PubMed score by year
PubTator Score  1.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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