Protein Summary
Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity). Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
- ENST00000210633
- ENSP00000210633
- ENSG00000095539
- ENST00000370250
- ENSP00000359270
- ENST00000517724
- ENSP00000430175
- ENST00000521006
- ENSP00000430881
- KIAA1619
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
cell line | 0.61 | ||
cell type or tissue | 0.6 | ||
transcription factor | 0.6 | ||
small molecule perturbation | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 44.73 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 53 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 44.73 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 53 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (83)
SCGB1D1
Novelty: 0.04199997
p_int: 0.998050168
p_ni: 0.000005904
p_wrong: 0.001943928
Score: 0.188
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Downstream (2)
1 – 2 of 2
Pathways (1)
KEGG (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Axon guidance | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (3)
Components (2)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
corneal topography | 3 | 1 | 3 | 84.6 | |||||
serum gamma-glutamyl transferase measurement | 1 | 2 | 2 | 58.3 | |||||
mitochondrial heteroplasmy measurement | 1 | 1 | 1 | 53.7 | |||||
refractive error measurement | 2 | 2 | 2 | 5.5 | 42.1 | ||||
puberty onset measurement | 1 | 1 | 1 | 33.1 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
corneal topography | 3 | 84.6 | |||||
serum gamma-glutamyl transferase measurement | 2 | 58.3 | |||||
mitochondrial heteroplasmy measurement | 1 | 53.7 | |||||
refractive error measurement | 2 | 5.5 | 42.1 | ||||
puberty onset measurement | 1 | 33.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | semaphorin 4G | 710879 | ||||||
Mouse | MGI:1347047 | 26456 | ||||||
Rat | RGD:1310436 | 361764 | ||||||
Dog | semaphorin 4G | VGNC:45998 | 486844 | |||||
Horse | semaphorin 4G | VGNC:22818 | 100070304 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | semaphorin 4G | |||||
Mouse | ||||||
Rat | ||||||
Dog | semaphorin 4G | |||||
Horse | semaphorin 4G | |||||
Publication Statistics
PubMed Score 44.73
PubMed score by year
PubTator Score 2.31
PubTator score by year
Related Publications
Text Mined References (13)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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