Tbio SEMA4G Semaphorin-4G

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Semaphorin-4g

DTO Classes

Protein / Signaling / Membrane-bound Signaling Molecule / Semaphorin-4g

Protein Summary

Description

Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity). Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• Q9NTN9
• A1A5C6
• A6NJY8
• Q58EY1
• Q9HCF3

Gene Name

• SEMA4G

Ensembl ID

• ENST00000210633
• ENSP00000210633
• ENSG00000095539
• ENST00000370250
• ENSP00000359270
• ENST00000517724
• ENSP00000430175
• ENST00000521006
• ENSP00000430881

Symbol

• KIAA1619

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
cell line	0.61
cell type or tissue	0.6
transcription factor	0.6
small molecule perturbation	0.57

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.73   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 53   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.73   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (12)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
corneal topography	EFO_0004345	3	1	3		84.6
serum gamma-glutamyl transferase measurement	EFO_0004532	1	2	2		58.3
mitochondrial heteroplasmy measurement	EFO_0600008	1	1	1		53.7
refractive error measurement	EFO_0007814	2	2	2	5.5	42.1
puberty onset measurement	EFO_0005677	1	1	1		33.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
corneal topography	EFO_0004345	3		84.6
serum gamma-glutamyl transferase measurement	EFO_0004532	2		58.3
mitochondrial heteroplasmy measurement	EFO_0600008	1		53.7
refractive error measurement	EFO_0007814	2	5.5	42.1
puberty onset measurement	EFO_0005677	1		33.1

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Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	semaphorin 4G		710879
Mouse	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G	MGI:1347047	26456
Rat	semaphorin 4G	RGD:1310436	361764
Dog	semaphorin 4G	VGNC:45998	486844
Horse	semaphorin 4G	VGNC:22818	100070304

Species	Name	OMA	EggNOG	Inparanoid
Macaque	semaphorin 4G
Mouse	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
Rat	semaphorin 4G
Dog	semaphorin 4G
Horse	semaphorin 4G

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q9NTN9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (1)

KEGG (1)

Find Similar Targets

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Axon guidance	180 targets	path:hsa04360

Name	Explore in Pharos	Explore in Source
Axon guidance	180 targets	path:hsa04360

Gene Ontology Terms (10)

Functions (3)

Components (2)

Processes (5)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
chemorepellent activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
neuropilin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
semaphorin receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (83)

Explore Interacting Targets

1 – 10 of 83

• See Interactions on String-DB

SCGB1D1

Tbio

Novelty:  0.04199997

p_int:  0.998050168

p_ni:  0.000005904

p_wrong:  0.001943928

Score:  0.188

Data Source:  BioPlex,STRINGDB

PLXND1

Tbio

Novelty:  0.01249713

Score:  0.915

Data Source:  STRINGDB

NRP2

Tbio

Novelty:  0.00764179

Score:  0.848

Data Source:  STRINGDB

NRP1

Tchem

Novelty:  0.00153628

Score:  0.847

Data Source:  STRINGDB

PLXNB1

Tbio

Novelty:  0.01073808

Score:  0.811

Data Source:  STRINGDB

EFNA2

Tbio

Novelty:  0.01184859

Score:  0.81

Data Source:  STRINGDB

PLXNB2

Tbio

Novelty:  0.01925055

Score:  0.806

Data Source:  STRINGDB

PLXNB3

Tbio

Novelty:  0.02948198

Score:  0.805

Data Source:  STRINGDB

EFNB3

Tbio

Novelty:  0.0120367

Score:  0.805

Data Source:  STRINGDB

EFNA3

Tbio

Novelty:  0.01819539

Score:  0.804

Data Source:  STRINGDB

Publication Statistics

PubMed Score  44.73

PubMed score by year

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PubTator Score  2.31

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

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Alternative splicing
Cell membrane
Complete proteome
Developmental protein
Differentiation
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Neurogenesis

GWAS Trait Find Similar Targets

No Header	No Header
age at onset
alkaline phosphatase measurement
body mass index
corneal topography
intraocular pressure measurement
mitochondrial DNA measurement
mitochondrial heteroplasmy measurement
Myopia
puberty onset measurement
refractive error measurement