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Tbio
SEMA4G
Semaphorin-4G

Protein Summary
Description
Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity). Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000210633
  • ENSP00000210633
  • ENSG00000095539
  • ENST00000370250
  • ENSP00000359270
  • ENST00000517724
  • ENSP00000430175
  • ENST00000521006
  • ENSP00000430881

Symbol
  • KIAA1619
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
cell line
0.61
cell type or tissue
0.6
transcription factor
0.6
small molecule perturbation
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.73   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.73   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
3
1
3
84.6
serum gamma-glutamyl transferase measurement
1
2
2
58.3
mitochondrial heteroplasmy measurement
1
1
1
53.7
refractive error measurement
2
2
2
5.5
42.1
puberty onset measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
3
84.6
serum gamma-glutamyl transferase measurement
2
58.3
mitochondrial heteroplasmy measurement
1
53.7
refractive error measurement
2
5.5
42.1
puberty onset measurement
1
33.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
semaphorin 4G
710879
Mouse
MGI:1347047
26456
Rat
RGD:1310436
361764
Dog
semaphorin 4G
VGNC:45998
486844
Horse
semaphorin 4G
VGNC:22818
100070304
Species
Name
OMA
EggNOG
Inparanoid
Macaque
semaphorin 4G
Mouse
Rat
Dog
semaphorin 4G
Horse
semaphorin 4G
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NTN9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (83)
1 – 10 of 83
SCGB1D1
Tbio
Novelty:  0.04199997
p_int:  0.998050168
p_ni:  0.000005904
p_wrong:  0.001943928
Score:  0.188
Data Source:  BioPlex,STRINGDB
PLXND1
Tbio
Novelty:  0.01249713
Score:  0.915
Data Source:  STRINGDB
NRP2
Tbio
Novelty:  0.00764179
Score:  0.848
Data Source:  STRINGDB
NRP1
Tchem
Novelty:  0.00153628
Score:  0.847
Data Source:  STRINGDB
PLXNB1
Tbio
Novelty:  0.01073808
Score:  0.811
Data Source:  STRINGDB
EFNA2
Tbio
Novelty:  0.01184859
Score:  0.81
Data Source:  STRINGDB
PLXNB2
Tbio
Novelty:  0.01925055
Score:  0.806
Data Source:  STRINGDB
PLXNB3
Tbio
Novelty:  0.02948198
Score:  0.805
Data Source:  STRINGDB
EFNB3
Tbio
Novelty:  0.0120367
Score:  0.805
Data Source:  STRINGDB
EFNA3
Tbio
Novelty:  0.01819539
Score:  0.804
Data Source:  STRINGDB
Publication Statistics
PubMed Score  44.73

PubMed score by year
PubTator Score  2.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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