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Tbio
SLC35D1
UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter

Protein Summary
Description
Transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm into the endoplasmic reticulum lumen (PubMed:11322953, PubMed:17952091). Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development (By similarity). Glycosylation of cellular glycoconjugates occurs in the endoplasmic reticulum (ER) and Golgi compartment, and requires transport of nucleotide sugars from the cytosol into the lumen of the ER and Golgi by specific transporters. The protein encoded by this gene resides in the ER, and transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm to the ER lumen. It may participate in glucuronidation and/or chondroitin sulfate biosynthesis. Mutations in this gene are associated with Schneckenbecken dysplasia.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000235345
  • ENSP00000235345
  • ENSG00000116704

Symbol
  • KIAA0260
  • UGTREL7
  • SHNKND
  • UGTREL7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
transcription factor perturbation
0.88
pathway
0.74
virus perturbation
0.72
biological process
0.7


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.83   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.83   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
2
3
89.2
monocyte count
1
1
1
54.4
blood urea nitrogen measurement
1
1
1
48.3
neutrophil percentage of leukocytes
2
2
2
39.1
leukocyte count
1
1
1
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
89.2
monocyte count
1
54.4
blood urea nitrogen measurement
1
48.3
neutrophil percentage of leukocytes
2
39.1
leukocyte count
1
36.9
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 35 member D1
VGNC:53217
745548
Macaque
solute carrier family 35 member D1
700175
Mouse
MGI:2140361
242585
Rat
RGD:1309843
298280
Dog
solute carrier family 35 member D1
VGNC:46370
100685241
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 35 member D1
Macaque
solute carrier family 35 member D1
Mouse
Rat
Dog
solute carrier family 35 member D1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NTN3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)
Reactome
Disease
Reactome
Diseases of metabolism
Reactome
Formation of the active cofactor, UDP-glucuronate
Name
Explore in Pharos
Explore in Source
Biological oxidations
Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)
Disease
Diseases of metabolism
Formation of the active cofactor, UDP-glucuronate
Protein-Protein Interactions (67)
1 – 10 of 67
SLC35B1
Tdark
Family: Transporter
Novelty: 0.33268269
Score: 0.912
Data Source: STRINGDB
B4GALT1
Tbio
Family: Enzyme
Novelty: 0.0073693
Score: 0.77
Data Source: STRINGDB
SLC35C2
Tdark
Family: Transporter
Novelty: 0.27116526
Score: 0.745
Data Source: STRINGDB
UAP1L1
Tdark
Family: Enzyme
Novelty: 0.36065169
Score: 0.734
Data Source: STRINGDB
SLC35B3
Tdark
Family: Transporter
Novelty: 0.10252233
Score: 0.729
Data Source: STRINGDB
SLC35A3
Tbio
Family: Transporter
Novelty: 0.02472244
Score: 0.721
Data Source: STRINGDB
SLC37A4
Tchem
Family: Transporter
Novelty: 0.00787533
Score: 0.696
Data Source: STRINGDB
SLC35A1
Tbio
Family: Transporter
Novelty: 0.02071929
Score: 0.691
Data Source: STRINGDB
SLC35B2
Tbio
Family: Transporter
Novelty: 0.01516638
Score: 0.666
Data Source: STRINGDB
FASTKD2
Tbio
Family: Enzyme
Novelty: 0.12614412
Score: 0.637
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.83

PubMed score by year
PubTator Score  6.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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