Tbio CUTC Copper homeostasis protein cutC homolog

Protein Summary

Description

May play a role in copper homeostasis. Can bind one Cu(1+) per subunit. Members of the CUT family of copper transporters are associated with copper homeostasis and are involved in the uptake, storage, delivery, and efflux of copper (Gupta et al., 1995 [PubMed 7635807]; Li et al., 2005 [PubMed 16182249]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9NTM9
• Q5TCZ8
• Q9Y321

Gene Name

• CUTC

Ensembl ID

• ENST00000370476
• ENSP00000359507
• ENSG00000119929

Symbol

• CGI-32

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
histone modification site profile	0.93
transcription factor perturbation	0.88
transcription factor binding site profile	0.82
disease perturbation	0.62

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Copper Homeostasis Protein Cutc Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.38   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 173   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.38   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0