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Tbio
DEPP1
Protein DEPP1

Protein Summary
Description
Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS. The expression of this gene is induced by fasting as well as by progesterone. The protein encoded by this gene contains a t-synaptosome-associated protein receptor (SNARE) coiled-coil homology domain and a peroxisomal targeting signal. Production of the encoded protein leads to phosphorylation and activation of the transcription factor ELK1. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298295
  • ENSP00000298295
  • ENSG00000165507

Symbol
  • C10orf10
  • DEPP
  • FIG
  • FIG
  • DEPP
  • Fseg
  • C10orf10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.18   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 21   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.18   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 21   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEPP1, autophagy regulator
VGNC:11672
741864
Macaque
DEPP1, autophagy regulator
706321
Mouse
MGI:1918730
213393
Rat
RGD:1565700
500300
Dog
DEPP1, autophagy regulator
VGNC:49591
477754
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEPP1, autophagy regulator
Macaque
DEPP1, autophagy regulator
Mouse
Rat
Dog
DEPP1, autophagy regulator
Gene Ontology Terms (5)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (26)
1 – 10 of 26
CRNN
Tbio
Novelty: 0.01648731
Score: 0.931
Data Source: STRINGDB
RPTN
Tbio
Novelty: 0.08523633
Score: 0.93
Data Source: STRINGDB
C6orf203
Tdark
Novelty: 1.12956468
Score: 0.591
Data Source: STRINGDB
ZSWIM4
Tdark
Novelty: 0.96500196
Score: 0.588
Data Source: STRINGDB
CSRNP3
Tdark
Novelty: 0.49305974
Score: 0.587
Data Source: STRINGDB
FOXO3
Tbio
Family: TF
Novelty: 0.00074316
Score: 0.562
Data Source: STRINGDB
TMEM65
Tdark
Novelty: 0.35968506
Score: 0.562
Data Source: STRINGDB
TTC9
Tdark
Novelty: 0.1679064
Score: 0.559
Data Source: STRINGDB
RASEF
Tbio
Novelty: 0.08877022
Score: 0.532
Data Source: STRINGDB
CCDC58
Tdark
Novelty: 1.40672371
Score: 0.524
Data Source: STRINGDB
Publication Statistics
PubMed Score  40.18

PubMed score by year
PubTator Score  17.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer