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Tbio
SACM1L
Phosphatidylinositide phosphatase SAC1

Protein Summary
Description
Phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P) (PubMed:24209621). Has low activity towards PtdIns(3,5)P2 (By similarity). This gene encodes an integral membrane protein, which is localized to the endoplasmic reticulum, and functions as a phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol 3,5-bisphosphate. Deletion of this gene in mouse results in preimplantation lethality. Other studies suggest that this gene is also involved in the organization of golgi membranes and mitotic spindles. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame, downstream translation termination codon via a stop codon readthrough mechanism.[provided by RefSeq, Dec 2017]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
cellular component
0.92
hub protein
0.9
transcription factor binding site profile
0.85
disease perturbation
0.79


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.39   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.39   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SAC1 like phosphatidylinositide phosphatase
VGNC:14852
460317
Macaque
SAC1 like phosphatidylinositide phosphatase
714107
Mouse
MGI:1933169
83493
Rat
RGD:69223
116482
Dog
SAC1 like phosphatidylinositide phosphatase
VGNC:45841
484795
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SAC1 like phosphatidylinositide phosphatase
Macaque
SAC1 like phosphatidylinositide phosphatase
Mouse
Rat
Dog
SAC1 like phosphatidylinositide phosphatase
Pathways (12)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Reactome
Synthesis of PIPs at the ER membrane
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Synthesis of PIPs at the ER membrane
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (176)
1 – 10 of 176
CMKLR1
Tchem
Family: GPCR
Novelty: 0.00893083
p_int: 0.994073158
p_ni: 0.005926842
Data Source: BioPlex
JTB
Tbio
Novelty: 0.06646216
p_int: 0.994059062
p_ni: 0.005940938
Data Source: BioPlex
EVA1C
Tbio
Novelty: 0.45928677
p_int: 0.982257178
p_ni: 0.017742822
Data Source: BioPlex
EVA1B
Tdark
Novelty: 2.1380272
p_int: 0.966946678
p_ni: 0.033053322
Data Source: BioPlex
CD226
Tbio
Novelty: 0.00374102
p_int: 0.958632828
p_ni: 0.041367172
Data Source: BioPlex
P2RY12
Tclin
Family: GPCR
Novelty: 0.00035406
p_int: 0.925739719
p_ni: 0.074260281
Score: 0.183
Data Source: BioPlex,STRINGDB
CCR6
Tchem
Family: GPCR
Novelty: 0.00257933
p_int: 0.902728645
p_ni: 0.097271355
Data Source: BioPlex
PBXIP1
Tbio
Novelty: 0.15404864
p_int: 0.877322998
p_ni: 0.122677002
Data Source: BioPlex
LPAR1
Tchem
Family: GPCR
Novelty: 0.00318056
p_int: 0.842042109
p_ni: 0.157957891
Data Source: BioPlex
SLC22A9
Tbio
Family: Transporter
Novelty: 0.02212992
p_int: 0.775716284
p_ni: 0.224283716
Data Source: BioPlex
Publication Statistics
PubMed Score  194.39

PubMed score by year
PubTator Score  52.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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