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Tbio
SMC4
Structural maintenance of chromosomes protein 4

Protein Summary
Description
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome condensation and sister chromatid cohesion. The protein encoded by this gene is likely a subunit of the 13S condensin complex, which is involved in chromosome condensation. A pseudogene related to this gene is located on chromosome 2. [provided by RefSeq, Jun 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344722
  • ENSP00000341382
  • ENSG00000113810
  • ENST00000357388
  • ENSP00000349961
  • ENST00000462787
  • ENSP00000420734

Symbol
  • CAPC
  • SMC4L1
  • CAPC
  • CAP-C
  • SMC-4
  • SMC4L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
co-expressed gene
0.93
protein complex
0.89
disease perturbation
0.87
hub protein
0.82


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.74   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.74   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (18)
1 – 5 of 18
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
structural maintenance of chromosomes 4
VGNC:2566
460821
Macaque
structural maintenance of chromosomes 4
702615
Mouse
MGI:1917349
70099
Rat
RGD:1306680
295107
Dog
structural maintenance of chromosomes 4
VGNC:46545
478679
Species
Name
OMA
EggNOG
Inparanoid
Chimp
structural maintenance of chromosomes 4
Macaque
structural maintenance of chromosomes 4
Mouse
Rat
Dog
structural maintenance of chromosomes 4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NTJ3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Condensation of Prometaphase Chromosomes
Reactome
Condensation of Prophase Chromosomes
Reactome
M Phase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Condensation of Prometaphase Chromosomes
Condensation of Prophase Chromosomes
M Phase
Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (340)
1 – 10 of 340
NCAPH2
Tbio
Novelty: 0.12134933
p_int: 0.999248826
p_ni: 0.000751174
Score: 0.997
Data Source: BioPlex,STRINGDB
NCAPD2
Tbio
Novelty: 0.04960987
Score: 0.999
Data Source: STRINGDB
NCAPH
Tbio
Novelty: 0.01598076
Score: 0.999
Data Source: STRINGDB
NCAPD3
Tbio
Novelty: 0.02819003
Score: 0.999
Data Source: STRINGDB
SMC2
Tbio
Novelty: 0.06898543
Score: 0.999
Data Source: STRINGDB
NCAPG
Tbio
Novelty: 0.01777557
Score: 0.999
Data Source: STRINGDB
NCAPG2
Tbio
Novelty: 0.07545554
Score: 0.998
Data Source: STRINGDB
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
Score: 0.996
Data Source: STRINGDB
AURKB
Tchem
Family: Kinase
Novelty: 0.00100972
Score: 0.991
Data Source: STRINGDB
PLK1
Tchem
Family: Kinase
Novelty: 0.00062799
Score: 0.991
Data Source: STRINGDB
Publication Statistics
PubMed Score  64.74

PubMed score by year
PubTator Score  23.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer