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Tbio
PDS5B
Sister chromatid cohesion protein PDS5 homolog B

Protein Summary
Description
Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315596
  • ENSP00000313851
  • ENSG00000083642
  • ENST00000450460
  • ENSP00000401619

Symbol
  • APRIN
  • AS3
  • KIAA0979
  • AS3
  • APRIN
  • CG008
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
transcription factor perturbation
0.94
disease perturbation
0.9
kinase perturbation
0.88
drug perturbation
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.74   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.74   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
2
4
97.9
1
1
0
2
35.8
mean platelet volume
1
1
1
33.2
1
1
0
1.5
26.7
1
1
1
25.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
97.9
0
2
35.8
mean platelet volume
1
33.2
0
1.5
26.7
1
25.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PDS5 cohesin associated factor B
VGNC:5094
452530
Macaque
PDS5 cohesin associated factor B
721999
Mouse
MGI:2140945
100710
Rat
RGD:1310838
304218
Dog
PDS5 cohesin associated factor B
VGNC:44393
486014
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PDS5 cohesin associated factor B
Macaque
PDS5 cohesin associated factor B
Mouse
Rat
Dog
PDS5 cohesin associated factor B
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NTI5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cohesin Loading onto Chromatin
Reactome
Establishment of Sister Chromatid Cohesion
Reactome
M Phase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cohesin Loading onto Chromatin
Establishment of Sister Chromatid Cohesion
M Phase
Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (217)
1 – 10 of 217
GYPB
Tbio
Novelty: 0.00442195
p_int: 0.999941758
p_ni: 0.00005824
p_wrong: 2e-9
Score: 0.154
Data Source: BioPlex,STRINGDB
SEPT12
Tbio
Novelty: 0.06228277
p_int: 0.999935776
p_ni: 0.000064224
Score: 0.187
Data Source: BioPlex,STRINGDB
SLC30A4
Tbio
Family: Transporter
Novelty: 0.02209
p_int: 0.999817968
p_ni: 0.000182031
p_wrong: 1e-9
Score: 0.185
Data Source: BioPlex,STRINGDB
VIPR2
Tchem
Family: GPCR
Novelty: 0.00463802
p_int: 0.999793027
p_ni: 0.000206973
Data Source: BioPlex
CYB5B
Tbio
Novelty: 0.09395308
p_int: 0.99944885
p_ni: 0.00055115
Data Source: BioPlex
RAD21
Tbio
Novelty: 0.00270936
p_int: 0.999158109
p_ni: 0.000840709
p_wrong: 0.000001182
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
CHRM4
Tclin
Family: GPCR
Novelty: 0.00759817
p_int: 0.998792786
p_ni: 0.001207195
p_wrong: 2e-8
Data Source: BioPlex
LYPD3
Tbio
Novelty: 0.03248533
p_int: 0.998146638
p_ni: 0.001853359
p_wrong: 3e-9
Data Source: BioPlex
APLNR
Tchem
Family: GPCR
Novelty: 0.00224203
p_int: 0.996954768
p_ni: 0.003045232
Data Source: BioPlex
CMKLR1
Tchem
Family: GPCR
Novelty: 0.00893083
p_int: 0.99675506
p_ni: 0.00324494
Data Source: BioPlex
Publication Statistics
PubMed Score  336.74

PubMed score by year
PubTator Score  102.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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