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Tbio
PDS5B
Sister chromatid cohesion protein PDS5 homolog B

Protein Summary
Description
Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315596
  • ENSP00000313851
  • ENSG00000083642
  • ENST00000450460
  • ENSP00000401619

Symbol
  • APRIN
  • AS3
  • KIAA0979
  • AS3
  • APRIN
  • CG008
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
transcription factor perturbation
0.94
disease perturbation
0.9
kinase perturbation
0.88
drug perturbation
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 426.57   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 426.57   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (217)
GYPB
Tbio
Novelty:  0.00442195
p_int:  0.999941758
p_ni:  0.00005824
p_wrong:  2e-9
Score:  0.154
Data Source:  BioPlex,STRINGDB
SEPT12
Tbio
Novelty:  0.06228277
p_int:  0.999935776
p_ni:  0.000064224
Score:  0.187
Data Source:  BioPlex,STRINGDB
SLC30A4
Tbio
Family:  Transporter
Novelty:  0.02209
p_int:  0.999817968
p_ni:  0.000182031
p_wrong:  1e-9
Score:  0.185
Data Source:  BioPlex,STRINGDB
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.999793027
p_ni:  0.000206973
Data Source:  BioPlex
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.99944885
p_ni:  0.00055115
Data Source:  BioPlex
RAD21
Tbio
Novelty:  0.00270936
p_int:  0.999158109
p_ni:  0.000840709
p_wrong:  0.000001182
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
CHRM4
Tclin
Family:  GPCR
Novelty:  0.00759817
p_int:  0.998792786
p_ni:  0.001207195
p_wrong:  2e-8
Data Source:  BioPlex
LYPD3
Tbio
Novelty:  0.03248533
p_int:  0.998146638
p_ni:  0.001853359
p_wrong:  3e-9
Data Source:  BioPlex
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.996954768
p_ni:  0.003045232
Data Source:  BioPlex
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.99675506
p_ni:  0.00324494
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cohesin Loading onto Chromatin
Reactome
Establishment of Sister Chromatid Cohesion
Reactome
M Phase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cohesin Loading onto Chromatin
Establishment of Sister Chromatid Cohesion
M Phase
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
3
5
92.8
mean platelet volume
3
3
3
85
body height
3
3
3
82.9
platelet count
3
3
3
80.1
serum alanine aminotransferase measurement
2
2
2
63.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
92.8
mean platelet volume
3
85
body height
3
82.9
platelet count
3
80.1
serum alanine aminotransferase measurement
2
63.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PDS5 cohesin associated factor B
VGNC:5094
452530
Macaque
PDS5 cohesin associated factor B
721999
Mouse
MGI:2140945
100710
Rat
RGD:1310838
304218
Dog
PDS5 cohesin associated factor B
VGNC:44393
486014
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PDS5 cohesin associated factor B
Macaque
PDS5 cohesin associated factor B
Mouse
Rat
Dog
PDS5 cohesin associated factor B
Publication Statistics
PubMed Score 426.57
PubMed score by year
PubTator Score 102.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title