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Tchem
SIRT3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

Protein Summary
Description
NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:19535340). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090). Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO (PubMed:16788062, PubMed:18680753, PubMed:24121500, PubMed:24252090, PubMed:19535340). Contributes to the regulation of the cellular energy metabolism (PubMed:24252090). Important for regulating tissue-specific ATP levels (PubMed:18794531). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301). This gene encodes a member of the sirtuin family o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382743
  • ENSP00000372191
  • ENSG00000142082
  • ENST00000529382
  • ENSP00000437216

Symbol
  • SIR2L3
  • SIR2L3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
virus perturbation
0.88
biological term
0.79
histone modification site profile
0.78
transcription factor perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1202.56   (req: < 5)
Gene RIFs: 181   (req: <= 3)
Antibodies: 711   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1202.56   (req: >= 5)
Gene RIFs: 181   (req: > 3)
Antibodies: 711   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 43
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (43)
1 – 10 of 43
CHEMBL3806268
chemical structure image
CHEMBL2338812
chemical structure image
CHEMBL2332053
chemical structure image
CHEMBL2338811
chemical structure image
CHEMBL3804834
chemical structure image
CHEMBL3805950
chemical structure image
CHEMBL3889954
chemical structure image
CHEMBL2338818
chemical structure image
CHEMBL3781645
chemical structure image
CHEMBL2338809
chemical structure image
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
2
2
2
85.4
1
1
0
1.2
71.1
mean reticulocyte volume
1
1
1
33.2
monocyte count
1
1
1
32.9
lymphocyte count
1
1
1
32.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
2
85.4
0
1.2
71.1
mean reticulocyte volume
1
33.2
monocyte count
1
32.9
lymphocyte count
1
32.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
sirtuin 3
720737
Mouse
MGI:1927665
64384
Rat
RGD:1308374
293615
Dog
sirtuin 3
VGNC:46184
475933
Horse
sirtuin 3
VGNC:22988
100054908
Species
Name
OMA
EggNOG
Inparanoid
Macaque
sirtuin 3
Mouse
Rat
Dog
sirtuin 3
Horse
sirtuin 3
Protein Data Bank (28)
1 – 5 of 28
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (28)
FOXO-mediated transcription (R-HSA-9614085)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Mitochondrial biogenesis
Name
Explore in Pharos
Explore in Source
FOXO-mediated transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Gene expression (Transcription)
Generic Transcription Pathway
Mitochondrial biogenesis
Gene Ontology Terms (20)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (222)
1 – 10 of 222
LSM14B
Tdark
Novelty: 0.31832554
p_int: 0.998002835
p_ni: 0.001997165
Score: 0.234
Data Source: BioPlex,STRINGDB
ELP3
Tbio
Family: Epigenetic
Novelty: 0.0166061
p_int: 0.997855531
p_ni: 0.002134415
p_wrong: 0.000010054
Score: 0.455
Data Source: BioPlex,STRINGDB
MRPL42
Tbio
Novelty: 0.48241447
p_int: 0.995549019
p_ni: 0.004450981
Data Source: BioPlex
SDHA
Tbio
Family: Enzyme
Novelty: 0.00223171
p_int: 0.991376781
p_ni: 0.008623219
Score: 0.813
Data Source: BioPlex,STRINGDB
HSPD1
Tbio
Novelty: 0.00018924
p_int: 0.98328763
p_ni: 0.01671237
Score: 0.467
Data Source: BioPlex,STRINGDB
NDUFS7
Tclin
Family: Enzyme
Novelty: 0.01562198
p_int: 0.978917927
p_ni: 0.02108207
p_wrong: 3e-9
Score: 0.347
Data Source: BioPlex,STRINGDB
DMC1
Tbio
Novelty: 0.05445277
p_int: 0.970817021
p_ni: 0.029182979
Score: 0.31
Data Source: BioPlex,STRINGDB
CNP
Tbio
Family: Enzyme
Novelty: 0.00566142
p_int: 0.957016598
p_ni: 0.042983402
Score: 0.532
Data Source: BioPlex,STRINGDB
TRIM43
Tdark
Novelty: 0.48246393
p_int: 0.948868722
p_ni: 0.051131278
Score: 0.543
Data Source: BioPlex,STRINGDB
REG4
Tbio
Novelty: 0.01123311
p_int: 0.934997715
p_ni: 0.065002285
Score: 0.18
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1202.56

PubMed score by year
PubTator Score  371.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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