Tbio TENM2 Teneurin-2

Protein Summary

Description

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer. Isoform 2: Acts as a ligand of the ADGRL1 receptor. Mediates axon guidance and heterophilic cell-cell adhesion. Ten-2 intracellular domain: Induces gene transcription inhibition.

Uniprot Accession IDs

• Q9NT68
• Q9ULU2
• Ten-2

Gene Name

• TENM2

Ensembl ID

• ENST00000518659
• ENSP00000429430
• ENSG00000145934

Symbol

• KIAA1127
• ODZ2
• TNM2
• ODZ2
• TNM2
• ten-2
• TEN-M2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.99
cellular component	0.74
transcription factor perturbation	0.68
phenotype	0.64
microRNA	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.7   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 7   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.7   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 7   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0