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Tbio
TENM2
Teneurin-2

Protein Summary
Description
Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer. Isoform 2: Acts as a ligand of the ADGRL1 receptor. Mediates axon guidance and heterophilic cell-cell adhesion. Ten-2 intracellular domain: Induces gene transcription inhibition.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000518659
  • ENSP00000429430
  • ENSG00000145934

Symbol
  • KIAA1127
  • ODZ2
  • TNM2
  • ODZ2
  • TNM2
  • ten-2
  • TEN-M2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.99
cellular component
0.74
transcription factor perturbation
0.68
phenotype
0.64
microRNA
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.35   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 7   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.35   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 7   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
3
5
6
1
92.5
serum gamma-glutamyl transferase measurement
2
2
2
92.3
smoking behaviour measurement
1
3
3
74.1
mathematical ability
3
6
7
69.7
smoking behavior
1
1
1
59.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
6
1
92.5
serum gamma-glutamyl transferase measurement
2
92.3
smoking behaviour measurement
3
74.1
mathematical ability
7
69.7
smoking behavior
1
59.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
teneurin transmembrane protein 2
698750
Mouse
MGI:1345184
23964
Rat
RGD:727907
117242
Dog
teneurin transmembrane protein 2
VGNC:47247
489135
Horse
teneurin-2
100059419
Species
Name
OMA
EggNOG
Inparanoid
Macaque
teneurin transmembrane protein 2
Mouse
Rat
Dog
teneurin transmembrane protein 2
Horse
teneurin-2
Protein Structure (0 Structures, 8 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (29)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (31)
1 – 10 of 31
ADGRL1
Tbio
Family:  GPCR
Novelty:  0.00957739
Score:  0.663
Data Source:  STRINGDB
TEN1
Tbio
Novelty:  0.02194283
Score:  0.6
Data Source:  STRINGDB
ZFP36L1
Tbio
Novelty:  0.01977742
Score:  0.556
Data Source:  STRINGDB
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
Score:  0.551
Data Source:  STRINGDB
EPHB1
Tchem
Family:  Kinase
Novelty:  0.01424716
Score:  0.543
Data Source:  STRINGDB
ZIC2
Tbio
Family:  TF
Novelty:  0.00900257
Score:  0.517
Data Source:  STRINGDB
HDGFL2
Tbio
Family:  Epigenetic
Novelty:  0.11846257
Score:  0.505
Data Source:  STRINGDB
NRCAM
Tbio
Novelty:  0.00443497
Score:  0.483
Data Source:  STRINGDB
PCDHB15
Tdark
Novelty:  1.37571583
Score:  0.474
Data Source:  STRINGDB
KPNA1
Tbio
Novelty:  0.00863582
Score:  0.473
Data Source:  STRINGDB
Publication Statistics
PubMed Score  36.35

PubMed score by year
PubTator Score  49.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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