Tbio EMILIN3 EMILIN-3

Protein Summary

Uniprot Accession IDs

• Q9NT22
• Q495S5
• Q495S6
• Q495S7
• Q76KT4

Gene Name

• EMILIN3

Ensembl ID

• ENST00000332312
• ENSP00000332806
• ENSG00000183798

Symbol

• C20orf130
• EMILIN5
• EMILIN5
• C20orf130
• dJ620E11.4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.6
PubMedID	0.58
microRNA	0.54
tissue	0.52
cell line	0.47

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.93   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 78   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.93   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (9)

Explore Interacting Targets

1 – 9 of 9

• See Interactions on String-DB

CSN1S1

Tbio

Family:  Enzyme

Novelty:  0.00200522

p_int:  0.986296063

p_ni:  0.013703937

Score:  0.188

Data Source:  BioPlex,STRINGDB

TRIM10

Tbio

Novelty:  0.27685659

p_int:  0.982943148

p_ni:  0.017056852

Score:  0.188

Data Source:  BioPlex,STRINGDB

KLRG2

Tdark

Novelty:  1.19446694

p_int:  0.943837054

p_ni:  0.056162946

Data Source:  BioPlex

VWCE

Tbio

Novelty:  0.09328341

p_int:  0.936567432

p_ni:  0.063432568

Data Source:  BioPlex

MMP10

Tchem

Novelty:  0.00112113

p_int:  0.852677616

p_ni:  0.147322384

Score:  0.188

Data Source:  BioPlex,STRINGDB

MFAP5

Tbio

Novelty:  0.01839035

p_int:  0.847795273

p_ni:  0.152204727

Data Source:  BioPlex

PLAUR

Tchem

Family:  Enzyme

Novelty:  0.00087642

p_int:  0.772771802

p_ni:  0.227228198

Data Source:  BioPlex

ZNRD1

Tbio

Family:  Enzyme

Novelty:  0.02269677

Score:  0.706

Data Source:  STRINGDB

EMID1

Tbio

Novelty:  0.14161673

Score:  0.419

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (1)

Components (2)

Processes (1)

Find Similar Targets

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
extracellular matrix constituent conferring elasticity	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL

Disease Associations ()

No disease associations found

GWAS Traits (13)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 13

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	2	1	2		80.6
BMI-adjusted waist-hip ratio	EFO_0007788	1	2	2		65.7
waist-hip ratio	EFO_0004343	1	2	2		65.7
total cholesterol measurement	EFO_0004574	2	2	3		58.2
hip circumference	EFO_0005093	1	2	2		42.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 13

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	2		80.6
BMI-adjusted waist-hip ratio	EFO_0007788	2		65.7
waist-hip ratio	EFO_0004343	2		65.7
total cholesterol measurement	EFO_0004574	3		58.2
hip circumference	EFO_0005093	2		42.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Coiled coil
Complete proteome
Disulfide bond
Extracellular matrix
Glycoprotein
Polymorphism
Reference proteome
Secreted
Signal

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist-hip ratio
coronary artery disease
depressive symptom measurement
hip circumference
low density lipoprotein cholesterol measurement
multiple sclerosis
myocardial infarction
platelet count
platelet crit
sex hormone-binding globulin measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	elastin microfibril interfacer 3	VGNC:6102	458256
Mouse	elastin microfibril interfacer 3	MGI:2389142	280635
Rat	elastin microfibril interfacer 3	RGD:1309607	362262
Dog	elastin microfibril interfacer 3	VGNC:40345	485877
Horse	elastin microfibril interfacer 3	VGNC:51535	100070579

Species	Name	OMA	EggNOG	Inparanoid
Chimp	elastin microfibril interfacer 3
Mouse	elastin microfibril interfacer 3
Rat	elastin microfibril interfacer 3
Dog	elastin microfibril interfacer 3
Horse	elastin microfibril interfacer 3

Publication Statistics

PubMed Score 2.93

PubMed score by year

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PubTator Score 3.12

PubTator score by year

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Related Publications

Text Mined References (11)

GeneRif Annotations (4)

Items per page:

10

0 of 0

PMID	Year	Title