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Tchem
BMP2K
BMP-2-inducible protein kinase

Protein Summary
Description
May be involved in osteoblast differentiation. This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335016
  • ENSP00000334836
  • ENSG00000138756
  • ENST00000502871
  • ENSP00000421768

Symbol
  • BIKE
  • BIKE
  • HRIHFB2017
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
kinase perturbation
0.99
small molecule
0.98
interacting protein
0.94
molecular function
0.94


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.54   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.54   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
92.6
red blood cell distribution width
2
3
3
76.3
self reported educational attainment
1
1
1
57.1
red blood cell density measurement
1
1
1
43.5
reticulocyte count
2
2
3
36.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
92.6
red blood cell distribution width
3
76.3
self reported educational attainment
1
57.1
red blood cell density measurement
1
43.5
reticulocyte count
3
36.6
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BMP2 inducible kinase
VGNC:10823
471194
Mouse
MGI:2155456
140780
Dog
BMP2 inducible kinase
VGNC:38479
487819
Opossum
BMP2 inducible kinase
100018895
Chicken
BMP2 inducible kinase
CGNC:8272
422578
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BMP2 inducible kinase
Mouse
Dog
BMP2 inducible kinase
Opossum
BMP2 inducible kinase
Chicken
BMP2 inducible kinase
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (56)
1 – 10 of 56
AP2M1
Tbio
Novelty: 0.00769368
p_int: 0.999999433
p_ni: 5.67e-7
Score: 0.754
Data Source: BioPlex,STRINGDB
AP2S1
Tbio
Novelty: 0.01931502
p_int: 0.999999196
p_ni: 8.04e-7
Score: 0.791
Data Source: BioPlex,STRINGDB
CLINT1
Tbio
Novelty: 0.00945381
p_int: 0.999992429
p_ni: 0.000007571
Score: 0.813
Data Source: BioPlex,STRINGDB
REPS1
Tbio
Novelty: 0.08952347
p_int: 0.999981525
p_ni: 0.000018475
Score: 0.977
Data Source: BioPlex,STRINGDB
PICALM
Tbio
Novelty: 0.00800832
p_int: 0.999954359
p_ni: 0.000045641
Score: 0.876
Data Source: BioPlex,STRINGDB
STAMBP
Tbio
Novelty: 0.01543821
p_int: 0.999853768
p_ni: 0.000146232
Score: 0.688
Data Source: BioPlex,STRINGDB
STAMBPL1
Tbio
Family: Enzyme
Novelty: 0.08532786
p_int: 0.999695276
p_ni: 0.000304723
Score: 0.698
Data Source: BioPlex,STRINGDB
RALBP1
Tbio
Novelty: 0.01525176
p_int: 0.999360846
p_ni: 0.000639154
Score: 0.914
Data Source: BioPlex,STRINGDB
INTS4
Tdark
Novelty: 0.20868831
p_int: 0.998542316
p_ni: 0.001457679
p_wrong: 6e-9
Score: 0.153
Data Source: BioPlex,STRINGDB
SLC25A41
Tdark
Family: Transporter
Novelty: 1.04918395
p_int: 0.998126256
p_ni: 0.00187374
p_wrong: 3e-9
Score: 0.288
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  12.54

PubMed score by year
PubTator Score  19.13

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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