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Tdark
NRBP2
Nuclear receptor-binding protein 2

Protein Summary
Description
May regulate apoptosis of neural progenitor cells during their differentiation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000442628
  • ENSP00000414055
  • ENSG00000185189

Symbol
  • TRG16
  • pp9320
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
histone modification site profile
0.72
virus perturbation
0.68
microRNA
0.57
cell line
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.72   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.72   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
PHF19
Tbio
Family:  Epigenetic
Novelty:  0.02289037
p_int:  0.999999428
p_ni:  5.14e-7
p_wrong:  5.8e-8
Score:  0.235
Data Source:  BioPlex,STRINGDB
TSC22D4
Tbio
Family:  TF
Novelty:  0.25451456
p_int:  0.999881119
p_ni:  9e-9
p_wrong:  0.000118872
Score:  0.306
Data Source:  BioPlex,STRINGDB
IL16
Tbio
Novelty:  0.0023276
p_int:  0.997773828
p_ni:  0.000181919
p_wrong:  0.002044252
Score:  0.416
Data Source:  BioPlex,STRINGDB
PUF60
Tbio
Novelty:  0.02667356
Score:  0.736
Data Source:  STRINGDB
TMEM53
Tdark
Novelty:  0.75877723
Score:  0.704
Data Source:  STRINGDB
RNF220
Tbio
Family:  Enzyme
Novelty:  0.14024436
Score:  0.669
Data Source:  STRINGDB
EPPK1
Tdark
Novelty:  0.03621061
Score:  0.658
Data Source:  STRINGDB
BTBD2
Tbio
Novelty:  0.23314987
Score:  0.592
Data Source:  STRINGDB
ARMH1
Tdark
Novelty:  3.31143233
Score:  0.587
Data Source:  STRINGDB
MCF2L
Tbio
Novelty:  0.05810416
Score:  0.559
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
2
2
2.3
94.5
mean platelet volume
2
1
2
85.4
platelet crit
1
1
1
83.6
red blood cell density measurement
1
1
1
58.4
diastolic blood pressure
2
2
2
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2.3
94.5
mean platelet volume
2
85.4
platelet crit
1
83.6
red blood cell density measurement
1
58.4
diastolic blood pressure
2
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor binding protein 2
VGNC:13194
107976469
Rat
RGD:1591749
680451
Dog
nuclear receptor binding protein 2
VGNC:43962
609556
Cow
nuclear receptor binding protein 2
VGNC:32256
504664
Opossum
nuclear receptor binding protein 2
100017096
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor binding protein 2
Rat
Dog
nuclear receptor binding protein 2
Cow
nuclear receptor binding protein 2
Opossum
nuclear receptor binding protein 2
Publication Statistics
PubMed Score 4.72
PubMed score by year
PubTator Score 1.54
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title