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Tbio
DIAPH3
Protein diaphanous homolog 3

Protein Summary
Description
Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity. This gene encodes a member of the diaphanous subfamily of the formin family. Members of this family are involved in actin remodeling and regulate cell movement and adhesion. Mutations in this gene are associated with autosomal dominant auditory neuropathy 1. Multiple transcript variants encoding different isoforms have been f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267215
  • ENSP00000267215
  • ENSG00000139734
  • ENST00000377908
  • ENSP00000367141
  • ENST00000400319
  • ENSP00000383173
  • ENST00000400320
  • ENSP00000383174
  • ENST00000400324
  • ENSP00000383178
  • ENST00000465066
  • ENSP00000478137
  • ENST00000498416
  • ENSP00000479091

Symbol
  • DIAP3
  • AN
  • DIA2
  • DRF3
  • AUNA1
  • NSDAN
  • diap3
  • mDia2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
protein domain
0.97
trait
0.93
hub protein
0.92
transcription factor binding site profile
0.86


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.76   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.76   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (157)
S100A4
Tchem
Novelty:  0.00136919
p_int:  0.999999487
p_ni:  5.13e-7
Data Source:  BioPlex
ENPP6
Tbio
Family:  Enzyme
Novelty:  0.06933544
p_int:  0.99999516
p_ni:  0.000004837
p_wrong:  3e-9
Data Source:  BioPlex
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.99997974
p_ni:  0.00002026
Score:  0.159
Data Source:  BioPlex,STRINGDB
TPTE2
Tbio
Family:  Enzyme
Novelty:  0.04710658
p_int:  0.999939315
p_ni:  0.000060685
Data Source:  BioPlex
CCDC183
Tdark
Novelty:  1.55719016
p_int:  0.997992365
p_ni:  0.002007635
Data Source:  BioPlex
PNKD
Tbio
Family:  Enzyme
Novelty:  0.02456078
p_int:  0.995753342
p_ni:  0.004246658
p_wrong:  1e-9
Data Source:  BioPlex
BCHE
Tclin
Family:  Enzyme
Novelty:  0.00031267
p_int:  0.995353887
p_ni:  0.004646107
p_wrong:  6e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
VASN
Tbio
Novelty:  0.05424159
p_int:  0.990878813
p_ni:  0.009121187
Data Source:  BioPlex
TMEM126A
Tbio
Novelty:  0.11759225
p_int:  0.979898971
p_ni:  0.02010045
p_wrong:  5.79e-7
Score:  0.682
Data Source:  BioPlex,STRINGDB
HS2ST1
Tbio
Family:  Enzyme
Novelty:  0.04520207
p_int:  0.962355878
p_ni:  0.037644122
Score:  0.163
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
1 – 5 of 6
CHRM4
Tclin
Family:  GPCR
KEGG Distance:  4
Common Pathways:  1
BDKRB2
Tclin
Family:  GPCR
KEGG Distance:  4
Common Pathways:  1
CHRM5
Tclin
Family:  GPCR
KEGG Distance:  4
Common Pathways:  1
CHRM2
Tclin
Family:  GPCR
KEGG Distance:  4
Common Pathways:  1
CHRM3
Tclin
Family:  GPCR
KEGG Distance:  4
Common Pathways:  1
Pathways (21)
RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate Formins
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
RHO GTPase Effectors
RHO GTPases Activate Formins
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
3
3
73.1
smoking status measurement
2
2
2
64.2
age at first sexual intercourse measurement
2
1
2
63.1
insomnia measurement
1
2
0
1.1
57.1
mathematical ability
1
1
1
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
73.1
smoking status measurement
2
64.2
age at first sexual intercourse measurement
2
63.1
insomnia measurement
0
1.1
57.1
mathematical ability
1
48.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
diaphanous related formin 3
VGNC:5055
452752
Mouse
MGI:1927222
56419
Rat
RGD:1593287
290396
Dog
diaphanous related formin 3
VGNC:39957
485474
Horse
diaphanous related formin 3
VGNC:17185
100051814
Species
Name
OMA
EggNOG
Inparanoid
Chimp
diaphanous related formin 3
Mouse
Rat
Dog
diaphanous related formin 3
Horse
diaphanous related formin 3
Publication Statistics
PubMed Score 98.76
PubMed score by year
PubTator Score 22.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title