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Tbio
TREX1
Three-prime repair exonuclease 1

Protein Summary
Description
Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. This gene encodes a nuclea ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000444177
  • ENSP00000415972
  • ENSG00000213689
  • ENST00000625293
  • ENSP00000486676

Symbol
  • CRV
  • AGS1
  • DRN3
  • HERNS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
virus perturbation
0.94
cellular component
0.71
transcription factor binding site profile
0.66
phenotype
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.59   (req: < 5)
Gene RIFs: 65   (req: <= 3)
Antibodies: 258   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.59   (req: >= 5)
Gene RIFs: 65   (req: > 3)
Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
3
3
86.3
mathematical ability
3
2
4
81.6
BMI-adjusted waist circumference
1
2
2
81
BMI-adjusted waist-hip ratio
2
2
2
79.6
macrophage inflammatory protein 1b measurement
1
1
1
74.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
86.3
mathematical ability
4
81.6
BMI-adjusted waist circumference
2
81
BMI-adjusted waist-hip ratio
2
79.6
macrophage inflammatory protein 1b measurement
1
74.4
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1328317
22040
Rat
RGD:1311998
100049583
Horse
three prime repair exonuclease 1
VGNC:24486
100063767
Cow
three prime repair exonuclease 1
VGNC:36303
282099
Anole lizard
three prime repair exonuclease 1
100561159
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
three prime repair exonuclease 1
Cow
three prime repair exonuclease 1
Anole lizard
three prime repair exonuclease 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NSU2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (23)
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
IRF3-mediated induction of type I IFN
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Regulation by TREX1
Name
Explore in Pharos
Explore in Source
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Immune System
Innate Immune System
Regulation by TREX1
Gene Ontology Terms (20)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (24)
1 – 10 of 24
RAB23
Tbio
Family:  Enzyme
Novelty:  0.01686155
p_int:  0.999971283
p_ni:  0.000028717
p_wrong:  1e-9
Score:  0.544
Data Source:  BioPlex,STRINGDB
ACTA2
Tbio
Novelty:  0.00199354
p_int:  0.899122843
p_ni:  0.100877157
Score:  0.163
Data Source:  BioPlex,STRINGDB
RNASEH2A
Tbio
Family:  Enzyme
Novelty:  0.00478657
Score:  0.768
Data Source:  STRINGDB
RNASEH2C
Tbio
Family:  Enzyme
Novelty:  0.06148299
Score:  0.748
Data Source:  STRINGDB
RNASEH2B
Tbio
Family:  Enzyme
Novelty:  0.02210045
Score:  0.748
Data Source:  STRINGDB
CHCHD2
Tbio
Novelty:  0.01615338
Score:  0.726
Data Source:  STRINGDB
HTRA1
Tchem
Family:  Enzyme
Novelty:  0.0016879
Score:  0.651
Data Source:  STRINGDB
EXO1
Tbio
Family:  Enzyme
Novelty:  0.00130104
Score:  0.587
Data Source:  STRINGDB
SAMHD1
Tbio
Family:  Enzyme
Novelty:  0.00294595
Score:  0.586
Data Source:  STRINGDB
SCAND1
Tbio
Novelty:  0.06863895
Score:  0.584
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1.59

PubMed score by year
PubTator Score  128.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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