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Tbio
PNPLA3
1-acylglycerol-3-phosphate O-acyltransferase PNPLA3

Protein Summary
Description
Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA (PubMed:22560221). Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides (PubMed:15364929, PubMed:20034933, PubMed:22560221). The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216180
  • ENSP00000216180
  • ENSG00000100344
  • ENST00000423180
  • ENSP00000397987

Symbol
  • ADPN
  • C22orf20
  • ADPN
  • C22orf20
  • iPLA(2)epsilon
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
phenotype
0.91
biological term
0.85
histone modification site profile
0.75
trait
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 683.8   (req: < 5)
Gene RIFs: 249   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 683.8   (req: >= 5)
Gene RIFs: 249   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
5
4
8
37.7
98.8
serum alanine aminotransferase measurement
8
4
8
6
98.8
7
4
1
1.7
96.9
liver fibrosis measurement
3
3
9
96.7
hemoglobin measurement
4
3
5
95.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
8
37.7
98.8
serum alanine aminotransferase measurement
8
6
98.8
1
1.7
96.9
liver fibrosis measurement
9
96.7
hemoglobin measurement
5
95.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
patatin like phospholipase domain containing 3
VGNC:5300
107970265
Macaque
patatin like phospholipase domain containing 3
712340
Mouse
MGI:2151796
116939
Rat
RGD:1595843
362972
Dog
patatin like phospholipase domain containing 3
VGNC:44754
609368
Species
Name
OMA
EggNOG
Inparanoid
Chimp
patatin like phospholipase domain containing 3
Macaque
patatin like phospholipase domain containing 3
Mouse
Rat
Dog
patatin like phospholipase domain containing 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NST1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Acyl chain remodeling of DAG and TAG (R-HSA-1482883)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodeling of DAG and TAG
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Acyl chain remodeling of DAG and TAG
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Gene Ontology Terms (24)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (94)
1 – 10 of 94
SLC27A2
Tbio
Family:  Transporter
Novelty:  0.01436035
p_int:  0.964647678
p_ni:  0.035352322
Score:  0.464
Data Source:  BioPlex,STRINGDB
PEX14
Tbio
Novelty:  0.0210557
p_int:  0.830416947
p_ni:  0.169583053
Score:  0.519
Data Source:  BioPlex,STRINGDB
LIPE
Tchem
Family:  Enzyme
Novelty:  0.00169872
Score:  0.976
Data Source:  STRINGDB
LIPC
Tchem
Family:  Enzyme
Novelty:  0.00219107
Score:  0.959
Data Source:  STRINGDB
LPL
Tchem
Family:  Enzyme
Novelty:  0.00057058
Score:  0.939
Data Source:  STRINGDB
MGLL
Tchem
Family:  Enzyme
Novelty:  0.00196912
Score:  0.932
Data Source:  STRINGDB
TM6SF2
Tbio
Novelty:  0.00965899
Score:  0.921
Data Source:  STRINGDB
AGK
Tbio
Family:  Enzyme
Novelty:  0.00919083
Score:  0.901
Data Source:  STRINGDB
DGAT2
Tchem
Family:  Enzyme
Novelty:  0.00488581
Score:  0.851
Data Source:  STRINGDB
PNLIP
Tclin
Family:  Enzyme
Novelty:  0.00043254
Score:  0.851
Data Source:  STRINGDB
Publication Statistics
PubMed Score  683.80

PubMed score by year
PubTator Score  405.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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