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Tbio
SNTG1
Gamma-1-syntrophin

Protein Summary
Description
Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity). May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation. The protein encoded by this gene is a member of the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that typically contain 2 pleckstrin homology (PH) domains, a PDZ domain that bisects the first PH domain, and a C-terminal domain that mediates dystrophin binding. This family member plays a role in mediating gamma-enolase trafficking to the plasma membrane and in enhancing its neurotrophic activity. Mutations in this gene are associated with idiopathic scoliosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000517473
  • ENSP00000431123
  • ENSG00000147481
  • ENST00000518864
  • ENSP00000429276
  • ENST00000522124
  • ENSP00000429842
  • ENST00000642720
  • ENSP00000493900

Symbol
  • SYN4
  • G1SYN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
trait
0.75
protein domain
0.73
cell line
0.72
metabolite
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.7   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.7   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (75)
1 – 10 of 75
DMD
Tclin
Novelty: 0.00029078
p_int: 0.999999999
p_ni: 1e-9
Score: 0.958
Data Source: BioPlex,STRINGDB
DTNA
Tbio
Novelty: 0.00529818
p_int: 0.999999988
p_ni: 1.2e-8
Score: 0.841
Data Source: BioPlex,STRINGDB
SNTB1
Tbio
Novelty: 0.07544233
p_int: 0.999999983
p_ni: 1.7e-8
Score: 0.821
Data Source: BioPlex,STRINGDB
SNTA1
Tbio
Novelty: 0.03034237
p_int: 0.999999982
p_ni: 1.8e-8
Score: 0.817
Data Source: BioPlex,STRINGDB
CTNNAL1
Tbio
Novelty: 0.07754085
p_int: 0.999999955
p_ni: 4.5e-8
Data Source: BioPlex
DTNB
Tbio
Novelty: 0.08092486
p_int: 0.999999845
p_ni: 1.55e-7
Score: 0.885
Data Source: BioPlex,STRINGDB
SNTB2
Tbio
Novelty: 0.05905256
p_int: 0.999998904
p_ni: 0.000001096
Score: 0.823
Data Source: BioPlex,STRINGDB
MLYCD
Tchem
Family: Enzyme
Novelty: 0.02336888
p_int: 0.999997131
p_ni: 0.000002869
Data Source: BioPlex
LRRC4B
Tdark
Novelty: 0.41088581
p_int: 0.999564645
p_ni: 0.000361618
p_wrong: 0.000073737
Score: 0.17
Data Source: BioPlex,STRINGDB
UTRN
Tbio
Novelty: 0.00225431
p_int: 0.999180186
p_ni: 0.00012629
p_wrong: 0.000693525
Score: 0.775
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  27.70

PubMed score by year
PubTator Score  21.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer