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Tbio
SNTG1
Gamma-1-syntrophin

Protein Summary
Description
Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity). May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation. The protein encoded by this gene is a member of the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that typically contain 2 pleckstrin homology (PH) domains, a PDZ domain that bisects the first PH domain, and a C-terminal domain that mediates dystrophin binding. This family member plays a role in mediating gamma-enolase trafficking to the plasma membrane and in enhancing its neurotrophic activity. Mutations in this gene are associated with idiopathic scoliosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000517473
  • ENSP00000431123
  • ENSG00000147481
  • ENST00000518864
  • ENSP00000429276
  • ENST00000522124
  • ENSP00000429842
  • ENST00000642720
  • ENSP00000493900

Symbol
  • SYN4
  • G1SYN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
trait
0.75
protein domain
0.73
cell line
0.72
metabolite
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.35   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.35   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
DMD
Tclin
Novelty:  0.00025661
p_int:  0.999999999
p_ni:  1e-9
Score:  0.958
Data Source:  BioPlex,STRINGDB
DTNA
Tbio
Novelty:  0.01165754
p_int:  0.999999988
p_ni:  1.2e-8
Score:  0.841
Data Source:  BioPlex,STRINGDB
SNTB1
Tbio
Novelty:  0.05324344
p_int:  0.999999983
p_ni:  1.7e-8
Score:  0.821
Data Source:  BioPlex,STRINGDB
SNTA1
Tbio
Novelty:  0.01668288
p_int:  0.999999982
p_ni:  1.8e-8
Score:  0.817
Data Source:  BioPlex,STRINGDB
CTNNAL1
Tbio
Novelty:  0.03667606
p_int:  0.999999955
p_ni:  4.5e-8
Data Source:  BioPlex
DTNB
Tbio
Novelty:  0.0586565
p_int:  0.999999845
p_ni:  1.55e-7
Score:  0.885
Data Source:  BioPlex,STRINGDB
SNTB2
Tbio
Novelty:  0.05469501
p_int:  0.999998904
p_ni:  0.000001096
Score:  0.823
Data Source:  BioPlex,STRINGDB
MLYCD
Tchem
Family:  Enzyme
Novelty:  0.01670441
p_int:  0.999997131
p_ni:  0.000002869
Data Source:  BioPlex
LRRC4B
Tbio
Novelty:  0.21762254
p_int:  0.999564645
p_ni:  0.000361618
p_wrong:  0.000073737
Score:  0.17
Data Source:  BioPlex,STRINGDB
UTRN
Tchem
Novelty:  0.0018541
p_int:  0.999180186
p_ni:  0.00012629
p_wrong:  0.000693525
Score:  0.775
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
1
1
1
48.5
smoking status measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
1
48.5
smoking status measurement
1
35
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syntrophin gamma 1
VGNC:14594
464170
Macaque
syntrophin gamma 1
709244
Mouse
MGI:1918346
71096
Rat
RGD:1560290
500394
Dog
syntrophin gamma 1
VGNC:46615
486943
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syntrophin gamma 1
Macaque
syntrophin gamma 1
Mouse
Rat
Dog
syntrophin gamma 1
Publication Statistics
PubMed Score 19.35
PubMed score by year
PubTator Score 21.65
PubTator score by year
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Related Publications
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PMID
Year
Title