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Tdark
KLC4
Kinesin light chain 4

Protein Summary
Description
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259708
  • ENSP00000259708
  • ENSG00000137171
  • ENST00000347162
  • ENSP00000340221
  • ENST00000394056
  • ENSP00000377620
  • ENST00000453940
  • ENSP00000395806
  • ENST00000458460
  • ENSP00000410358
  • ENST00000467906
  • ENSP00000418759
  • ENST00000479388
  • ENSP00000418031

Symbol
  • KNSL8
  • KNSL8
  • bA387M24.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
interacting protein
0.96
protein domain
0.92
kinase perturbation
0.76
cell type or tissue
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.56   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.56   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (188)
1 – 10 of 188
MYCL
Tbio
Family:  TF
Novelty:  0.0034508
p_int:  0.999999937
p_ni:  6.3e-8
Data Source:  BioPlex
SYNE4
Tbio
Novelty:  0.0739848
p_int:  0.9999996
p_ni:  4e-7
Score:  0.348
Data Source:  BioPlex,STRINGDB
KLC1
Tbio
Novelty:  0.00653484
p_int:  0.99999901
p_ni:  9.9e-7
Score:  0.993
Data Source:  BioPlex,STRINGDB
TRIP6
Tbio
Novelty:  0.02183202
p_int:  0.999995551
p_ni:  0.000004446
p_wrong:  2e-9
Score:  0.226
Data Source:  BioPlex,STRINGDB
COG6
Tbio
Novelty:  0.02874093
p_int:  0.999947279
p_ni:  0.000052719
p_wrong:  2e-9
Score:  0.161
Data Source:  BioPlex,STRINGDB
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
p_int:  0.99986651
p_ni:  0.000133489
Data Source:  BioPlex
NUP43
Tbio
Novelty:  0.11571309
p_int:  0.9998631
p_ni:  0.000136899
Score:  0.158
Data Source:  BioPlex,STRINGDB
KPTN
Tbio
Novelty:  0.06841936
p_int:  0.999794615
p_ni:  0.000205385
Score:  0.173
Data Source:  BioPlex,STRINGDB
AZIN1
Tbio
Family:  Enzyme
Novelty:  0.03017595
p_int:  0.999779462
p_ni:  0.000220534
p_wrong:  4e-9
Score:  0.568
Data Source:  BioPlex,STRINGDB
KIF2B
Tbio
Novelty:  0.09958244
p_int:  0.999642345
p_ni:  0.000357655
Score:  0.915
Data Source:  BioPlex,STRINGDB
Pathways (17)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
COPI-dependent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Hemostasis
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
2
2
2
84.9
high density lipoprotein cholesterol measurement
2
2
3
79.6
apolipoprotein B measurement
2
2
2
76.5
bilirubin measurement
1
1
1
67.3
homocysteine measurement
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
2
84.9
high density lipoprotein cholesterol measurement
3
79.6
apolipoprotein B measurement
2
76.5
bilirubin measurement
1
67.3
homocysteine measurement
1
47.7
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin light chain 4
VGNC:3263
735843
Macaque
kinesin light chain 4
698356
Mouse
MGI:1922014
74764
Rat
RGD:1306555
316226
Dog
kinesin light chain 4
VGNC:42429
474909
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin light chain 4
Macaque
kinesin light chain 4
Mouse
Rat
Dog
kinesin light chain 4
Publication Statistics
PubMed Score 3.56
PubMed score by year
PubTator Score 1.61
PubTator score by year