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Tbio
BRWD1
Bromodomain and WD repeat-containing protein 1

Protein Summary
Description
May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcription ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333229
  • ENSP00000330753
  • ENSG00000185658
  • ENST00000341322
  • ENSP00000342106
  • ENST00000342449
  • ENSP00000344333
  • ENST00000380800
  • ENSP00000370178

Symbol
  • C21orf107
  • WDR9
  • N143
  • WDR9
  • WRD9
  • DCAF19
  • C21orf107
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
kinase perturbation
0.99
microRNA
0.96
transcription factor binding site profile
0.94
transcription factor perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.84   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.84   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (73)
1 – 10 of 73
SMARCA4
Tchem
Family:  Epigenetic
Novelty:  0.00112496
Score:  0.966
Data Source:  Reactome,STRINGDB
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
Score:  0.943
Data Source:  STRINGDB
STAT5B
Tchem
Family:  TF
Novelty:  0.00074178
Score:  0.942
Data Source:  STRINGDB
RAG2
Tbio
Family:  Epigenetic
Novelty:  0.00100277
Score:  0.908
Data Source:  STRINGDB
RAG1
Tbio
Novelty:  0.00070687
Score:  0.904
Data Source:  STRINGDB
PSMG1
Tbio
Novelty:  0.08175356
Score:  0.836
Data Source:  STRINGDB
PHIP
Tbio
Family:  Epigenetic
Novelty:  0.02496083
Score:  0.825
Data Source:  STRINGDB
ATRX
Tbio
Novelty:  0.00114798
Score:  0.779
Data Source:  STRINGDB
BPTF
Tchem
Family:  Epigenetic
Novelty:  0.00826037
Score:  0.73
Data Source:  STRINGDB
BIRC6
Tbio
Novelty:  0.01187953
Score:  0.703
Data Source:  STRINGDB
Pathways (6)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-7 signaling
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Cytokine Signaling in Immune system
Immune System
Interleukin-7 signaling
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
GWAS Traits (46)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
4
3
4
87.4
C-reactive protein measurement
4
3
4
85.2
4
2
1
1.3
84.6
fibrinogen measurement
4
2
4
72.7
2
2
0
1.2
72.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
4
87.4
C-reactive protein measurement
4
85.2
1
1.3
84.6
fibrinogen measurement
4
72.7
0
1.2
72.2
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
bromodomain and WD repeat domain containing 1
715714
Mouse
MGI:1890651
93871
Rat
RGD:1309030
304061
Dog
bromodomain and WD repeat domain containing 1
VGNC:38536
487764
Horse
bromodomain and WD repeat domain containing 1
VGNC:15899
100059579
Species
Name
OMA
EggNOG
Inparanoid
Macaque
bromodomain and WD repeat domain containing 1
Mouse
Rat
Dog
bromodomain and WD repeat domain containing 1
Horse
bromodomain and WD repeat domain containing 1
Publication Statistics
PubMed Score 12.84
PubMed score by year
PubTator Score 4.94
PubTator score by year