Tbio BRWD1 Bromodomain and WD repeat-containing protein 1

Protein Summary

Description

May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011]

Uniprot Accession IDs

• Q9NSI6
• C9JK25
• O43721
• Q5R2V0
• Q5R2V1
• Q6P2D1
• Q8TCV3
• Q96QG9
• Q96QH0
• Q9NUK1

Gene Name

• BRWD1

Ensembl ID

• ENST00000333229
• ENSP00000330753
• ENSG00000185658
• ENST00000341322
• ENSP00000342106
• ENST00000342449
• ENSP00000344333
• ENST00000380800
• ENSP00000370178

Symbol

• C21orf107
• WDR9
• N143
• WDR9
• WRD9
• DCAF19
• C21orf107

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
kinase perturbation	0.99
microRNA	0.96
transcription factor binding site profile	0.94
transcription factor perturbation	0.91

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.72   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 88   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.72   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0