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Tbio
CISH
Cytokine-inducible SH2-containing protein

Protein Summary
Description
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348721
  • ENSP00000294173
  • ENSG00000114737
  • ENST00000443053
  • ENSP00000409346

Symbol
  • G18
  • CIS
  • G18
  • SOCS
  • CIS-1
  • BACTS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
transcription factor perturbation
0.88
transcription factor
0.77
gene perturbation
0.76
phenotype
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 553.58   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 553.58   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
1
1
13.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
13.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cytokine inducible SH2 containing protein
701456
Mouse
MGI:103159
12700
Rat
RGD:69261
83681
Dog
cytokine inducible SH2 containing protein
VGNC:39281
484757
Horse
cytokine inducible SH2 containing protein
VGNC:16558
100061510
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cytokine inducible SH2 containing protein
Mouse
Rat
Dog
cytokine inducible SH2 containing protein
Horse
cytokine inducible SH2 containing protein
Pathways (28)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Growth hormone receptor signaling
Reactome
Immune System
Reactome
Interleukin-7 signaling
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Growth hormone receptor signaling
Immune System
Interleukin-7 signaling
Metabolism of proteins
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (278)
1 – 10 of 278
CUL5
Tbio
Novelty: 0.00792494
p_int: 0.999374988
p_ni: 0.000625012
Score: 0.984
Data Source: BioPlex,STRINGDB
AMBRA1
Tbio
Novelty: 0.01626687
p_int: 0.903923787
p_ni: 0.096076213
Score: 0.379
Data Source: BioPlex,STRINGDB
ELOC
Tbio
Novelty: 0.00964847
Score: 0.99
Data Source: STRINGDB
ELOB
Tbio
Novelty: 0.01315739
Score: 0.986
Data Source: STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00074026
Score: 0.984
Data Source: STRINGDB
STAT5B
Tchem
Family: TF
Novelty: 0.00074178
Score: 0.982
Data Source: STRINGDB
CUL2
Tbio
Novelty: 0.00512916
Score: 0.976
Data Source: STRINGDB
SPSB1
Tbio
Novelty: 0.13839743
Score: 0.974
Data Source: STRINGDB
JAK2
Tclin
Family: Kinase
Novelty: 0.00022894
Score: 0.973
Data Source: Reactome,STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.972
Data Source: STRINGDB
Publication Statistics
PubMed Score  553.58

PubMed score by year
PubTator Score  545.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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