Tbio CISH Cytokine-inducible SH2-containing protein

Protein Summary

Description

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Uniprot Accession IDs

• Q9NSE2
• B2R9N1
• G5E9R1
• Q9NS38
• Q9Y5R1
• CIS

Gene Name

• CISH

Ensembl ID

• ENST00000348721
• ENSP00000294173
• ENSG00000114737
• ENST00000443053
• ENSP00000409346

Symbol

• G18
• CIS
• G18
• SOCS
• CIS-1
• BACTS2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.88
transcription factor perturbation	0.88
transcription factor	0.77
gene perturbation	0.76
phenotype	0.68

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Cytokine-inducible Sh2-containing Protein

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Cytokine-inducible Sh2-containing Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 706.37   (req: < 5)

Gene RIFs: 40   (req: <= 3)

Antibodies: 163   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 706.37   (req: >= 5)

Gene RIFs: 40   (req: > 3)

Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0