FARSB
Phenylalanine--tRNA ligase beta subunit
Protein Summary
This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
- ENST00000281828
- ENSP00000281828
- ENSG00000116120
- FARSLB
- FRSB
- FRSB
- PheHB
- PheRS
- FARSLB
- RILDBC
- HSPC173
- NEDBLLA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 1 | ||
interacting protein | 0.95 | ||
molecular function | 0.95 | ||
small molecule perturbation | 0.88 | ||
histone modification site profile | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.86 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 258 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.86 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 258 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0