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Tchem
RXFP3
Relaxin-3 receptor 1

Protein Summary
Description
Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330120
  • ENSP00000328708
  • ENSG00000182631
  • ENST00000616205
  • ENSP00000480733
  • ENSG00000277069

Symbol
  • RLN3R1
  • SALPR
  • SALPR
  • RLN3R1
  • RXFPR3
  • GPCR135
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.65
cell line
0.64
tissue
0.6
histone modification site profile
0.51
virus perturbation
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.66   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 247   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.66   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
135PAM1
chemical structure image
Pathways (13)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (245)
1 – 10 of 245
RLN3
Tbio
Novelty: 0.01243441
Score: 0.996
Data Source: Reactome,STRINGDB
INSL5
Tbio
Novelty: 0.03673832
Score: 0.985
Data Source: STRINGDB
RXFP1
Tchem
Family: GPCR
Novelty: 0.00590091
Score: 0.985
Data Source: STRINGDB
RXFP2
Tbio
Family: GPCR
Novelty: 0.01111071
Score: 0.969
Data Source: STRINGDB
DRD4
Tchem
Family: GPCR
Novelty: 0.00047256
Score: 0.944
Data Source: STRINGDB
SST
Tbio
Novelty: 0.0000732
Score: 0.939
Data Source: STRINGDB
TAS2R13
Tbio
Family: GPCR
Novelty: 0.49152154
Score: 0.923
Data Source: STRINGDB
GPR37L1
Tbio
Family: GPCR
Novelty: 0.11748252
Score: 0.922
Data Source: STRINGDB
GNG4
Tdark
Novelty: 0.2302777
Score: 0.92
Data Source: STRINGDB
GAL
Tbio
Novelty: 0.00057698
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score  60.66

PubMed score by year
PubTator Score  44.46

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer