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Tchem
SLC6A13
Sodium- and chloride-dependent GABA transporter 2

Protein Summary
Description
Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343164
  • ENSP00000339260
  • ENSG00000010379
  • ENST00000436453
  • ENSP00000389316
  • ENST00000445055
  • ENSP00000407104

Symbol
  • GAT2
  • GAT2
  • GAT3
  • GAT-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
molecular function
0.93
cell type or tissue
0.68
PubMedID
0.66
tissue
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.09   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.09   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0