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Tchem
SLC6A13
Sodium- and chloride-dependent GABA transporter 2

Protein Summary
Description
Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343164
  • ENSP00000339260
  • ENSG00000010379
  • ENST00000436453
  • ENSP00000389316
  • ENST00000445055
  • ENSP00000407104

Symbol
  • GAT2
  • GAT2
  • GAT3
  • GAT-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
molecular function
0.93
cell type or tissue
0.68
PubMedID
0.66
tissue
0.61


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.44   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.44   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
SNAP-5114
Rendered image for SNAP-5114
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
9
6
8
9.4
96.7
blood metabolite measurement
2
3
3
91.9
creatinine measurement
5
4
5
80.5
serum metabolite measurement
1
1
1
55.2
3-hydroxyisobutyrate measurement
1
1
1
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
8
9.4
96.7
blood metabolite measurement
3
91.9
creatinine measurement
5
80.5
serum metabolite measurement
1
55.2
3-hydroxyisobutyrate measurement
1
53.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 13
VGNC:8547
100614945
Mouse
MGI:95629
14412
Rat
RGD:620788
171163
Dog
solute carrier family 6 member 13
VGNC:46456
100856253
Horse
solute carrier family 6 member 13
VGNC:23253
100050539
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 13
Mouse
Rat
Dog
solute carrier family 6 member 13
Horse
solute carrier family 6 member 13
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NSD5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
GABA synthesis, release, reuptake and degradation (R-HSA-888590)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GABA synthesis, release, reuptake and degradation
Reactome
Na+/Cl- dependent neurotransmitter transporters
Reactome
Neuronal System
Reactome
Neurotransmitter release cycle
Reactome
Reuptake of GABA
Name
Explore in Pharos
Explore in Source
GABA synthesis, release, reuptake and degradation
Na+/Cl- dependent neurotransmitter transporters
Neuronal System
Neurotransmitter release cycle
Reuptake of GABA
Protein-Protein Interactions (49)
1 – 10 of 49
CASTOR3
Tdark
Novelty:  0.01099717
Score:  0.903
Data Source:  STRINGDB
SLC6A11
Tchem
Family:  Transporter
Novelty:  0.01324279
Score:  0.806
Data Source:  STRINGDB
GABRA5
Tclin
Family:  IC
Novelty:  0.01499706
Score:  0.762
Data Source:  STRINGDB
GABRD
Tclin
Family:  IC
Novelty:  0.0204242
Score:  0.734
Data Source:  STRINGDB
SLC32A1
Tchem
Family:  Transporter
Novelty:  0.00237273
Score:  0.712
Data Source:  STRINGDB
GABRR3
Tbio
Family:  IC
Novelty:  0.01890426
Score:  0.705
Data Source:  STRINGDB
GAD1
Tbio
Family:  Enzyme
Novelty:  0.00067443
Score:  0.625
Data Source:  STRINGDB
SLC1A2
Tchem
Family:  Transporter
Novelty:  0.00086733
Score:  0.614
Data Source:  STRINGDB
SLC1A3
Tchem
Family:  Transporter
Novelty:  0.00127305
Score:  0.612
Data Source:  STRINGDB
GAD2
Tbio
Family:  Enzyme
Novelty:  0.00058427
Score:  0.601
Data Source:  STRINGDB
Publication Statistics
PubMed Score  97.44

PubMed score by year
PubTator Score  41.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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