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Tbio
ST6GALNAC1
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1

Protein Summary
Description
Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000156626
  • ENSP00000156626
  • ENSG00000070526

Symbol
  • SIAT7A
  • STYI
  • SIAT7A
  • HSY11339
  • ST6GalNAcI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.62
tissue
0.56
virus perturbation
0.55
cellular component
0.54
pathway
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.93   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.93   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (10)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Sialic acid metabolism
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
Post-translational protein modification
Sialic acid metabolism
Protein-Protein Interactions (96)
1 – 10 of 96
EEF1A2
Tchem
Novelty: 0.001472
p_int: 0.817084938
p_ni: 0.182915061
Score: 0.8
Data Source: BioPlex,STRINGDB
C1GALT1
Tbio
Family: Enzyme
Novelty: 0.01191596
Score: 0.97
Data Source: STRINGDB
C1GALT1C1
Tbio
Family: Enzyme
Novelty: 0.01318017
Score: 0.969
Data Source: STRINGDB
GCNT1
Tbio
Family: Enzyme
Novelty: 0.01487872
Score: 0.966
Data Source: STRINGDB
B3GNT6
Tbio
Family: Enzyme
Novelty: 0.13176407
Score: 0.949
Data Source: STRINGDB
ST3GAL1
Tchem
Family: Enzyme
Novelty: 0.01236776
Score: 0.927
Data Source: STRINGDB
ST3GAL2
Tbio
Family: Enzyme
Novelty: 0.03503891
Score: 0.919
Data Source: STRINGDB
GALNT2
Tbio
Family: Enzyme
Novelty: 0.02458542
Score: 0.874
Data Source: STRINGDB
GALNT6
Tbio
Family: Enzyme
Novelty: 0.04627605
Score: 0.857
Data Source: STRINGDB
GALNT3
Tbio
Family: Enzyme
Novelty: 0.01140808
Score: 0.83
Data Source: STRINGDB
Publication Statistics
PubMed Score  186.93

PubMed score by year
PubTator Score  63.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer