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Tbio
HOMER3
Homer protein homolog 3

Protein Summary
Description
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation through negative regulation of IL2 expression by inhibiting calcineurin-NFAT pathway activation through interaction with NFATC2 leading to reduction of interaction between NFATC2 and PPP3CA (PubMed:18218901). This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper mot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221222
  • ENSP00000221222
  • ENSG00000051128
  • ENST00000392351
  • ENSP00000376162
  • ENST00000433218
  • ENSP00000396154
  • ENST00000539827
  • ENSP00000439937
  • ENST00000542541
  • ENSP00000446026
  • ENST00000594439
  • ENSP00000471835

Symbol
  • VESL3
  • HOMER-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
viral protein
1
virus
0.89
histone modification site profile
0.85
transcription factor
0.74
kinase perturbation
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.71   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.71   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homer scaffold protein 3
VGNC:2355
736171
Macaque
homer scaffolding protein 3
719647
Mouse
MGI:1347359
26558
Rat
RGD:620706
29548
Dog
homer scaffold protein 3
VGNC:41738
484813
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homer scaffold protein 3
Macaque
homer scaffolding protein 3
Mouse
Rat
Dog
homer scaffold protein 3
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NSC5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Neurexins and neuroligins (R-HSA-6794361)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Protein-Protein Interactions (84)
1 – 10 of 84
HOMER1
Tbio
Novelty: 0.00264721
p_int: 1
Score: 0.983
Data Source: BioPlex,Reactome,STRINGDB
HOMER2
Tbio
Novelty: 0.00820449
p_int: 0.999999999
p_ni: 1e-9
Score: 0.982
Data Source: BioPlex,Reactome,STRINGDB
FRYL
Tdark
Novelty: 0.13893531
p_int: 0.999999825
p_ni: 1.75e-7
Score: 0.54
Data Source: BioPlex,STRINGDB
IFIT2
Tbio
Novelty: 0.01023074
p_int: 0.999999606
p_ni: 3.94e-7
Score: 0.524
Data Source: BioPlex,STRINGDB
MPP5
Tbio
Novelty: 0.01707773
p_int: 0.999987718
p_ni: 0.000012282
Score: 0.205
Data Source: BioPlex,STRINGDB
PATJ
Tbio
Novelty: 0.01420008
p_int: 0.999952293
p_ni: 0.000047704
p_wrong: 2e-9
Score: 0.552
Data Source: BioPlex,STRINGDB
CEP192
Tbio
Novelty: 0.05738998
p_int: 0.9993818
p_ni: 0.000618148
p_wrong: 5.1e-8
Score: 0.173
Data Source: BioPlex,STRINGDB
HNRNPLL
Tbio
Novelty: 0.0498467
p_int: 0.998937694
p_ni: 0.001061235
p_wrong: 0.000001072
Data Source: BioPlex
PEX14
Tbio
Novelty: 0.0210557
p_int: 0.998591363
p_ni: 0.001408637
Data Source: BioPlex
DBN1
Tbio
Novelty: 0.00556156
p_int: 0.995441645
p_ni: 0.004558355
Score: 0.815
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  19.71

PubMed score by year
PubTator Score  13.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer