Tbio SALL1 Sal-like protein 1

Protein Summary

Description

Transcriptional repressor involved in organogenesis. The protein encoded by this gene is a zinc finger transcriptional repressor and may be part of the NuRD histone deacetylase complex (HDAC). Defects in this gene are a cause of Townes-Brocks syndrome (TBS) as well as bronchio-oto-renal syndrome (BOR). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NSC2
• Q99881
• Q9NSC3
• Q9P1R0

Gene Name

• SALL1

Ensembl ID

• ENST00000251020
• ENSP00000251020
• ENSG00000103449
• ENST00000440970
• ENSP00000407914

Symbol

• SAL1
• ZNF794
• TBS
• HSAL1
• Sal-1
• ZNF794
• HEL-S-89

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
PubMedID	0.81
molecular function	0.76
phenotype	0.7
cellular component	0.69

Protein Classes

PANTHER Classes

Protein / ... / C2h2 Zinc Finger Transcription Factor / Sal-like Protein 1

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / C2h2 Zinc Finger Transcription Factor / Sal-like Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 316.11   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 159   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 316.11   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0