Tbio SALL1 Sal-like protein 1

Protein Classes

PANTHER Classes

Protein / ... / C2h2 Zinc Finger Transcription Factor / Sal-like Protein 1

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / C2h2 Zinc Finger Transcription Factor / Sal-like Protein 1

Protein Summary

Description

Transcriptional repressor involved in organogenesis. The protein encoded by this gene is a zinc finger transcriptional repressor and may be part of the NuRD histone deacetylase complex (HDAC). Defects in this gene are a cause of Townes-Brocks syndrome (TBS) as well as bronchio-oto-renal syndrome (BOR). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NSC2
• Q99881
• Q9NSC3
• Q9P1R0

Gene Name

• SALL1

Ensembl ID

• ENST00000251020
• ENSP00000251020
• ENSG00000103449
• ENST00000440970
• ENSP00000407914

Symbol

• SAL1
• ZNF794
• TBS
• HSAL1
• Sal-1
• ZNF794
• HEL-S-89

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
PubMedID	0.81
molecular function	0.76
phenotype	0.7
cellular component	0.69

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 424.31   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 159   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 424.31   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (3)

Reactome (3)

Developmental Biology (R-HSA-1266738)

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Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	13 targets	R-HSA-2892247
Reactome	Transcriptional regulation of pluripotent stem cells	31 targets	R-HSA-452723

Name	Explore in Pharos	Explore in Source
Developmental Biology	1055 targets	R-HSA-1266738
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	13 targets	R-HSA-2892247
Transcriptional regulation of pluripotent stem cells	31 targets	R-HSA-452723

Gene Ontology Terms (39)

Functions (7)

Components (5)

Processes (27)

Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
beta-catenin binding	Inferred from Direct Assay (IDA)	UniProtKB
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA binding	Non-traceable Author Statement (NAS)	UniProtKB
DNA-binding transcription factor activity	Non-traceable Author Statement (NAS)	UniProtKB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific	Inferred from Electronic Annotation (IEA)	Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (87)

Explore Interacting Targets

1 – 10 of 87

• See Interactions on String-DB

VRTN

Tdark

Novelty: 0.06911874

p_int: 0.999999999

p_ni: 1e-9

Data Source: BioPlex

HPS1

Tbio

Novelty: 0.48

p_int: 0.999993926

p_ni: 0.000005522

p_wrong: 5.52e-7

Score: 0.416

Data Source: BioPlex,STRINGDB

DSN1

Tbio

Novelty: 0.08344924

p_int: 0.999305568

p_ni: 0.000015272

p_wrong: 0.00067916

Score: 0.188

Data Source: BioPlex,STRINGDB

RBBP7

Tbio

Novelty: 0.02883677

p_int: 0.998437214

p_ni: 0.000113265

p_wrong: 0.001449521

Score: 0.29

Data Source: BioPlex,STRINGDB

NANOG

Tbio

Family: TF

Novelty: 0.00073323

Score: 0.976

Data Source: STRINGDB

SOX2

Tbio

Family: TF

Novelty: 0.00050367

Score: 0.966

Data Source: STRINGDB

CCNQ

Tdark

Novelty: 0.1029793

Score: 0.958

Data Source: STRINGDB

POU5F1

Tbio

Family: TF

Novelty: 0.000425

Score: 0.948

Data Source: STRINGDB

SALL4

Tbio

Family: TF

Novelty: 0.00211387

Score: 0.919

Data Source: STRINGDB

SIX1

Tbio

Family: TF

Novelty: 0.00201882

Score: 0.801

Data Source: STRINGDB

Publication Statistics

PubMed Score  424.31

PubMed score by year

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PubTator Score  104.77

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MSRRKQAKPQHFQSDPEVASLPRRDGDTEKGQPSRPTKSKDAHVCGRCCAEFFELSDLLLHKKNCTKNQL

1-70

VLIVNENPASPPETFSPSPPPDNPDEQMNDTVNKTDQVDCSDLSEHNGLDREESMEVEAPVANKSGSGTS

70-140

SGSHSSTAPSSSSSSSSSSGGGGSSSTGTSAITTSLPQLGDLTTLGNFSVINSNVIIENLQSTKVAVAQF

140-210

SQEARCGGASGGKLAVPALMEQLLALQQQQIHQLQLIEQIRHQILLLASQNADLPTSSSPSQGTLRTSAN

210-280

PLSTLSSHLSQQLAAAAGLAQSLASQSASISGVKQLPPIQLPQSSSGNTIIPSNSGSSPNMNILAAAVTT

280-350

PSSEKVASSAGASHVSNPAVSSSSSPAFAISSLLSPASNPLLPQQASANSVFPSPLPNIGTTAEDLNSLS

350-420

ALAQQRKSKPPNVTAFEAKSTSDEAFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCNICGNRFSTKG

420-490

NLKVHFQRHKEKYPHIQMNPYPVPEHLDNIPTSTGIPYGMSIPPEKPVTSWLDTKPVLPTLTTSVGLPLP

490-560

PTLPSLIPFIKTEEPAPIPISHSATSPPGSVKSDSGGPESATRNLGGLPEEAEGSTLPPSGGKSEESGMV

560-630

TNSVPTASSSVLSSPAADCGPAGSATTFTNPLLPLMSEQFKAKFPFGGLLDSAQASETSKLQQLVENIDK

630-700

KATDPNECIICHRVLSCQSALKMHYRTHTGERPFKCKICGRAFTTKGNLKTHYSVHRAMPPLRVQHSCPI

700-770

CQKKFTNAVVLQQHIRMHMGGQIPNTPVPDSYSESMESDTGSFDEKNFDDLDNFSDENMEDCPEGSIPDT

770-840

PKSADASQDSLSSSPLPLEMSSIAALENQMKMINAGLAEQLQASLKSVENGSIEGDVLTNDSSSVGGDME

840-910

SQSAGSPAISESTSSMQALSPSNSTQEFHKSPSIEEKPQRAVPSEFANGLSPTPVNGGALDLTSSHAEKI

910-980

IKEDSLGILFPFRDRGKFKNTACDICGKTFACQSALDIHYRSHTKERPFICTVCNRGFSTKGNLKQHMLT

980-1050

HQMRDLPSQLFEPSSNLGPNQNSAVIPANSLSSLIKTEVNGFVHVSPQDSKDTPTSHVPSGPLSSSATSP

1050-1120

VLLPALPRRTPKQHYCNTCGKTFSSSSALQIHERTHTGEKPFACTICGRAFTTKGNLKVHMGTHMWNSTP

1120-1190

ARRGRRLSVDGPMTFLGGNPVKFPEMFQKDLAARSGSGDPSSFWNQYAAALSNGLAMKANEISVIQNGGI

1190-1260

PPIPGSLGSGNSSPVSGLTGNLERLQNSEPNAPLAGLEKMASSENGTNFRFTRFVEDSKEIVTS

1260-1324

MSRRKQAKPQHFQSDPEVASLPRRDGDTEKGQPSRPTKSKDAHVCGRCCAEFFELSDLLLHKKNCTKNQLVLIVNENPASPPETFSPSPPPDNPDEQMNDTVNKTDQVDCSDLSEHNGLDREESMEVEAPVANKSGSGTSSGSHSSTAPSSSSSSSSSSGGGGSSSTGTSAITTSLPQLGDLTTLGNFSVINSNVIIENLQSTKVAVAQFSQEARCGGASGGKLAVPALMEQLLALQQQQIHQLQLIEQIRHQILLLASQNADLPTSSSPSQGTLRTSANPLSTLSSHLSQQLAAAAGLAQSLASQSASISGVKQLPPIQLPQSSSGNTIIPSNSGSSPNMNILAAAVTTPSSEKVASSAGASHVSNPAVSSSSSPAFAISSLLSPASNPLLPQQASANSVFPSPLPNIGTTAEDLNSLSALAQQRKSKPPNVTAFEAKSTSDEAFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCNICGNRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEHLDNIPTSTGIPYGMSIPPEKPVTSWLDTKPVLPTLTTSVGLPLPPTLPSLIPFIKTEEPAPIPISHSATSPPGSVKSDSGGPESATRNLGGLPEEAEGSTLPPSGGKSEESGMVTNSVPTASSSVLSSPAADCGPAGSATTFTNPLLPLMSEQFKAKFPFGGLLDSAQASETSKLQQLVENIDKKATDPNECIICHRVLSCQSALKMHYRTHTGERPFKCKICGRAFTTKGNLKTHYSVHRAMPPLRVQHSCPICQKKFTNAVVLQQHIRMHMGGQIPNTPVPDSYSESMESDTGSFDEKNFDDLDNFSDENMEDCPEGSIPDTPKSADASQDSLSSSPLPLEMSSIAALENQMKMINAGLAEQLQASLKSVENGSIEGDVLTNDSSSVGGDMESQSAGSPAISESTSSMQALSPSNSTQEFHKSPSIEEKPQRAVPSEFANGLSPTPVNGGALDLTSSHAEKIIKEDSLGILFPFRDRGKFKNTACDICGKTFACQSALDIHYRSHTKERPFICTVCNRGFSTKGNLKQHMLTHQMRDLPSQLFEPSSNLGPNQNSAVIPANSLSSLIKTEVNGFVHVSPQDSKDTPTSHVPSGPLSSSATSPVLLPALPRRTPKQHYCNTCGKTFSSSSALQIHERTHTGEKPFACTICGRAFTTKGNLKVHMGTHMWNSTPARRGRRLSVDGPMTFLGGNPVKFPEMFQKDLAARSGSGDPSSFWNQYAAALSNGLAMKANEISVIQNGGIPPIPGSLGSGNSSPVSGLTGNLERLQNSEPNAPLAGLEKMASSENGTNFRFTRFVEDSKEIVTS

Find similar targets by:

Uniprot Keyword

Alternative splicing
Complete proteome
Deafness
DNA-binding
Isopeptide bond
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome