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Tdark
KRT82
Keratin, type II cuticular Hb2

Protein Summary
Description
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this keratin appears to be a hair cuticle-specific keratin. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257974
  • ENSP00000257974
  • ENSG00000161850

Symbol
  • KRTHB2
  • HB2
  • Hb-2
  • KRTHB2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.8
cell line
0.5
chemical
0.41
protein domain
0.41
hub protein
0.39


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.14   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.14   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (135)
1 – 10 of 135
KRT16
Tbio
Novelty:  0.00503235
Score:  0.947
Data Source:  STRINGDB
KRT35
Tbio
Novelty:  0.01111091
Score:  0.94
Data Source:  STRINGDB
KRT32
Tdark
Novelty:  1.12077627
Score:  0.936
Data Source:  STRINGDB
KRT38
Tdark
Novelty:  0.25061021
Score:  0.933
Data Source:  STRINGDB
KRT25
Tbio
Novelty:  0.21822685
Score:  0.933
Data Source:  STRINGDB
KRT34
Tbio
Novelty:  0.07747997
Score:  0.932
Data Source:  STRINGDB
KRT36
Tdark
Novelty:  0.50578568
Score:  0.931
Data Source:  STRINGDB
KRT27
Tdark
Novelty:  0.34729004
Score:  0.93
Data Source:  STRINGDB
KRT24
Tbio
Novelty:  0.06581895
Score:  0.93
Data Source:  STRINGDB
KRT37
Tdark
Novelty:  0.01643723
Score:  0.926
Data Source:  STRINGDB
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cutaneous squamous cell carcinoma
1
1
1
5.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cutaneous squamous cell carcinoma
1
5.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin 82
VGNC:8459
466990
Macaque
keratin 82
698695
Mouse
MGI:2149248
114566
Rat
RGD:1359276
366991
Dog
keratin 82
VGNC:42535
486525
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin 82
Macaque
keratin 82
Mouse
Rat
Dog
keratin 82
Publication Statistics
PubMed Score 1.14
PubMed score by year
PubTator Score 62.51
PubTator score by year