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Tdark
KRT84
Keratin, type II cuticular Hb4

Protein Summary
Description
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin is contained primarily in the filiform tongue papilla, among other hair keratins. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257951
  • ENSP00000257951
  • ENSG00000161849

Symbol
  • KRTHB4
  • HB4
  • KRTHB4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.71
cellular component
0.6
disease
0.6
cell type or tissue
0.55
gene perturbation
0.53


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.97   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.97   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin 84
VGNC:8460
466989
Macaque
keratin 84
698573
Mouse
MGI:96700
16680
Rat
RGD:1359402
315320
Dog
keratin 84
VGNC:42536
486526
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin 84
Macaque
keratin 84
Mouse
Rat
Dog
keratin 84
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NSB2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Protein-Protein Interactions (72)
1 – 10 of 72
KRT32
Tdark
Novelty: 1.12077627
Score: 0.937
Data Source: STRINGDB
KRT35
Tbio
Novelty: 0.01111091
Score: 0.934
Data Source: STRINGDB
KRT36
Tdark
Novelty: 0.50578568
Score: 0.931
Data Source: STRINGDB
KRT34
Tbio
Novelty: 0.07747997
Score: 0.929
Data Source: STRINGDB
KRT38
Tdark
Novelty: 0.25061021
Score: 0.926
Data Source: STRINGDB
KRT14
Tbio
Novelty: 0.00088743
Score: 0.925
Data Source: STRINGDB
KRT16
Tbio
Novelty: 0.00503235
Score: 0.925
Data Source: STRINGDB
KRT17
Tbio
Novelty: 0.00278761
Score: 0.925
Data Source: STRINGDB
KRT9
Tbio
Novelty: 0.00787691
Score: 0.925
Data Source: STRINGDB
KRT25
Tbio
Novelty: 0.21822685
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.97

PubMed score by year
PubTator Score  24.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer