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Tbio
FGF21
Fibroblast growth factor 21

Protein Summary
Description
Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222157
  • ENSP00000222157
  • ENSG00000105550
  • ENST00000593756
  • ENSP00000471477
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
biological term
0.84
cell type or tissue
0.68
pathway
0.59
phenotype
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1285.67   (req: < 5)
Gene RIFs: 231   (req: <= 3)
Antibodies: 624   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1285.67   (req: >= 5)
Gene RIFs: 231   (req: > 3)
Antibodies: 624   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
energy intake
2
1
4
95.1
protein intake measurement
1
1
1
85.5
sugar consumption measurement
1
1
1
81.5
triglyceride measurement
3
1
3
75.9
carbohydrate intake measurement
1
1
1
75.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
energy intake
4
95.1
protein intake measurement
1
85.5
sugar consumption measurement
1
81.5
triglyceride measurement
3
75.9
carbohydrate intake measurement
1
75.1
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (43)
Assembly of active LPL and LIPC lipase complexes (R-HSA-8963889)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of active LPL and LIPC lipase complexes
Reactome
Cellular hexose transport
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein remodeling
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Assembly of active LPL and LIPC lipase complexes
Cellular hexose transport
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein remodeling
SLC-mediated transmembrane transport
Gene Ontology Terms (26)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (172)
1 – 10 of 172
FGFR1
Tclin
Family: Kinase
Novelty: 0.00055714
Score: 0.977
Data Source: STRINGDB
KLB
Tbio
Family: Enzyme
Novelty: 0.00446813
Score: 0.952
Data Source: STRINGDB
CREB3L3
Tbio
Family: TF
Novelty: 0.02519904
Score: 0.952
Data Source: STRINGDB
FGFR4
Tclin
Family: Kinase
Novelty: 0.00258329
Score: 0.919
Data Source: STRINGDB
FGFR2
Tclin
Family: Kinase
Novelty: 0.00066613
Score: 0.906
Data Source: STRINGDB
INS
Tbio
Novelty: 0.00000499
Score: 0.901
Data Source: STRINGDB
FGFR3
Tclin
Family: Kinase
Novelty: 0.00071612
Score: 0.893
Data Source: STRINGDB
UCP1
Tbio
Novelty: 0.00055954
Score: 0.849
Data Source: STRINGDB
ADIPOQ
Tbio
Novelty: 0.00011196
Score: 0.839
Data Source: STRINGDB
KL
Tbio
Family: Enzyme
Novelty: 0.00096954
Score: 0.824
Data Source: STRINGDB
Publication Statistics
PubMed Score  1285.67

PubMed score by year
PubTator Score  532.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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