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Tbio
FGF21
Fibroblast growth factor 21

Protein Summary
Description
Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222157
  • ENSP00000222157
  • ENSG00000105550
  • ENST00000593756
  • ENSP00000471477
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
biological term
0.84
cell type or tissue
0.68
pathway
0.59
phenotype
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1382.05   (req: < 5)
Gene RIFs: 231   (req: <= 3)
Antibodies: 624   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1382.05   (req: >= 5)
Gene RIFs: 231   (req: > 3)
Antibodies: 624   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (172)
FGFR1
Tclin
Family:  Kinase
Novelty:  0.00055714
Score:  0.977
Data Source:  STRINGDB
KLB
Tbio
Family:  Enzyme
Novelty:  0.00446813
Score:  0.952
Data Source:  STRINGDB
CREB3L3
Tbio
Family:  TF
Novelty:  0.02519904
Score:  0.952
Data Source:  STRINGDB
FGFR4
Tclin
Family:  Kinase
Novelty:  0.00258329
Score:  0.919
Data Source:  STRINGDB
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
Score:  0.906
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.901
Data Source:  STRINGDB
FGFR3
Tclin
Family:  Kinase
Novelty:  0.00071612
Score:  0.893
Data Source:  STRINGDB
UCP1
Tbio
Novelty:  0.00055954
Score:  0.849
Data Source:  STRINGDB
ADIPOQ
Tbio
Novelty:  0.00011196
Score:  0.839
Data Source:  STRINGDB
KL
Tbio
Family:  Enzyme
Novelty:  0.00096954
Score:  0.824
Data Source:  STRINGDB
Nearest Tclin Targets (18)
Explore Nearest Tclin Targets
Pathways (43)
Assembly of active LPL and LIPC lipase complexes (R-HSA-8963889)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of active LPL and LIPC lipase complexes
Reactome
Cellular hexose transport
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein remodeling
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Assembly of active LPL and LIPC lipase complexes
Cellular hexose transport
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein remodeling
SLC-mediated transmembrane transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (74)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
3
9
8
2.3
99.4
alkaline phosphatase measurement
4
6
5
16.2
99.4
low density lipoprotein cholesterol measurement
5
11
15
98.7
apolipoprotein B measurement
2
6
6
97.5
total cholesterol measurement
3
9
13
96.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
8
2.3
99.4
alkaline phosphatase measurement
5
16.2
99.4
low density lipoprotein cholesterol measurement
15
98.7
apolipoprotein B measurement
6
97.5
total cholesterol measurement
13
96.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor 21
VGNC:2406
468948
Macaque
fibroblast growth factor 21
718288
Mouse
MGI:1861377
56636
Rat
RGD:620175
170580
Dog
fibroblast growth factor 21
VGNC:40848
484395
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor 21
Macaque
fibroblast growth factor 21
Mouse
Rat
Dog
fibroblast growth factor 21
Publication Statistics
PubMed Score 1382.05
PubMed score by year
PubTator Score 532.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title