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Tclin
SLC22A11
Solute carrier family 22 member 11

Protein Summary
Description
Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds. The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301891
  • ENSP00000301891
  • ENSG00000168065
  • ENST00000377585
  • ENSP00000366809

Symbol
  • OAT4
  • OAT4
  • hOAT4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
0.98
chemical
0.68
molecular function
0.56
cell type or tissue
0.51
virus perturbation
0.5


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.54   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.54   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
probenecid
chemical structure image
Active Ligands (1)
1 – 1 of 1
cephalothin
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
4
4
5
10.5
99.2
urate measurement
5
4
6
6.8
99.1
testosterone measurement
3
1
3
93
body mass index
1
1
1
38.4
overweight body mass index status
1
2
2
33.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
5
10.5
99.2
urate measurement
6
6.8
99.1
testosterone measurement
3
93
body mass index
1
38.4
overweight body mass index status
2
33.7
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 22 member 11
VGNC:7756
466654
Macaque
solute carrier family 22 member 11
699212
Dog
solute carrier family 22 member 11
VGNC:46272
612103
Cow
solute carrier family 22 member 11
VGNC:34720
518926
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 22 member 11
Macaque
solute carrier family 22 member 11
Dog
solute carrier family 22 member 11
Cow
solute carrier family 22 member 11
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NSA0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Organic anion transport (R-HSA-561048)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Organic anion transport
Reactome
Organic cation/anion/zwitterion transport
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Organic anion transport
Organic cation/anion/zwitterion transport
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Protein-Protein Interactions (43)
1 – 10 of 43
SLC2A9
Tbio
Family: Transporter
Novelty: 0.00683926
Score: 0.845
Data Source: STRINGDB
SLC17A1
Tbio
Family: Transporter
Novelty: 0.0127372
Score: 0.839
Data Source: STRINGDB
SLC17A3
Tbio
Family: Transporter
Novelty: 0.04671795
Score: 0.792
Data Source: STRINGDB
PDZK1
Tbio
Novelty: 0.01129974
Score: 0.773
Data Source: STRINGDB
ABCG2
Tchem
Family: Transporter
Novelty: 0.00029779
Score: 0.745
Data Source: STRINGDB
SLC16A9
Tbio
Family: Transporter
Novelty: 0.06564904
Score: 0.74
Data Source: STRINGDB
CARMIL1
Tbio
Novelty: 0.04162135
Score: 0.706
Data Source: STRINGDB
ABCC4
Tchem
Family: Transporter
Novelty: 0.00208051
Score: 0.678
Data Source: STRINGDB
SLC7A13
Tdark
Family: Transporter
Novelty: 0.20907223
Score: 0.632
Data Source: STRINGDB
SLCO4C1
Tbio
Family: Transporter
Novelty: 0.04138167
Score: 0.632
Data Source: STRINGDB
Publication Statistics
PubMed Score  71.54

PubMed score by year
PubTator Score  57.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer