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Tbio
RAD18
E3 ubiquitin-protein ligase RAD18

Protein Summary
Description
E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264926
  • ENSP00000264926
  • ENSG00000070950

Symbol
  • RNF73
  • RNF73
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.88
protein domain
0.85
histone modification site profile
0.84
hub protein
0.82
molecular function
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.26   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 370   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.26   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 370   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
DNA Damage Bypass (R-HSA-73893)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Bypass
Reactome
DNA Repair
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
DNA Damage Bypass
DNA Repair
E3 ubiquitin ligases ubiquitinate target proteins
Metabolism of proteins
Post-translational protein modification
Gene Ontology Terms (29)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (253)
1 – 10 of 253
LLGL2
Tbio
Novelty: 0.10375119
p_int: 0.999999924
p_ni: 7.6e-8
Data Source: BioPlex
JPH4
Tbio
Novelty: 0.02095843
p_int: 0.999999736
p_ni: 2.64e-7
Data Source: BioPlex
MAGEA4
Tbio
Novelty: 0.00987373
p_int: 0.999994381
p_ni: 0.000005619
Score: 0.305
Data Source: BioPlex,STRINGDB
ZNF692
Tbio
Family: TF
Novelty: 0.06511123
p_int: 0.999969942
p_ni: 0.000030057
p_wrong: 1e-9
Data Source: BioPlex
UBE2B
Tbio
Novelty: 0.02464704
p_int: 0.999920751
p_ni: 0.000079249
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
IRF9
Tbio
Family: TF
Novelty: 0.01154411
p_int: 0.999852642
p_ni: 0.000147358
Score: 0.177
Data Source: BioPlex,STRINGDB
PIP4K2A
Tbio
Family: Kinase
Novelty: 0.01482796
p_int: 0.999776815
p_ni: 0.000223185
Data Source: BioPlex
ZFP41
Tdark
Family: TF
Novelty: 11
p_int: 0.999391575
p_ni: 0.000608371
p_wrong: 5.4e-8
Data Source: BioPlex
JUNB
Tbio
Family: TF
Novelty: 0.01119828
p_int: 0.999268527
p_ni: 0.000731467
p_wrong: 5e-9
Score: 0.223
Data Source: BioPlex,STRINGDB
TXNIP
Tbio
Novelty: 0.00279977
p_int: 0.999262698
p_ni: 0.000737302
Data Source: BioPlex
Publication Statistics
PubMed Score  178.26

PubMed score by year
PubTator Score  180.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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