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Tchem
CYSLTR2
Cysteinyl leukotriene receptor 2

Protein Summary
Description
Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4. The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282018
  • ENSP00000282018
  • ENSG00000152207
  • ENST00000614739
  • ENSP00000477930

Symbol
  • CYSLT2
  • CYSLT2R
  • HG57
  • CYSLT2
  • GPCR21
  • HPN321
  • CYSLT2R
  • KPG_011
  • hGPCR21
  • PSEC0146
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.67
cell type or tissue
0.63
microRNA
0.61
ligand (chemical)
0.59
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.74   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.74   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 44
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Active Ligands (44)
1 – 10 of 44
LTD<sub>4</sub>
chemical structure image
LTE<sub>4</sub>
chemical structure image
BAYu9773
chemical structure image
CHEMBL22776
chemical structure image
LTC<sub>4</sub>
chemical structure image
N-methyl LTC<sub>4</sub>
chemical structure image
CHEMBL3597619
chemical structure image
CHEMBL3597620
chemical structure image
CHEMBL3597626
chemical structure image
Pathways (13)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Eicosanoid ligand-binding receptors
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Eicosanoid ligand-binding receptors
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Protein-Protein Interactions (182)
1 – 10 of 182
LTB4R2
Tchem
Family: GPCR
Novelty: 0.01094048
Score: 0.977
Data Source: STRINGDB
PLCB4
Tbio
Family: Enzyme
Novelty: 0.01840915
Score: 0.951
Data Source: STRINGDB
TBXA2R
Tclin
Family: GPCR
Novelty: 0.00571066
Score: 0.946
Data Source: STRINGDB
CYSLTR1
Tclin
Family: GPCR
Novelty: 0.00337777
Score: 0.944
Data Source: STRINGDB
GNAQ
Tbio
Novelty: 0.0008997
Score: 0.94
Data Source: STRINGDB
GNA11
Tbio
Novelty: 0.00128664
Score: 0.938
Data Source: STRINGDB
PTGER1
Tclin
Family: GPCR
Novelty: 0.0013716
Score: 0.935
Data Source: STRINGDB
LTB4R
Tchem
Family: GPCR
Novelty: 0.00354427
Score: 0.927
Data Source: STRINGDB
PTGFR
Tclin
Family: GPCR
Novelty: 0.00560908
Score: 0.919
Data Source: STRINGDB
MLNR
Tchem
Family: GPCR
Novelty: 0.0048579
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score  110.74

PubMed score by year
PubTator Score  96.93

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer