Tbio MBIP MAP3K12-binding inhibitory protein 1

Protein Summary

Description

Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Uniprot Accession IDs

• Q9NS73
• Q86TZ2
• Q96AS5
• Q9BS93
• Q9NZE1

Gene Name

• MBIP

Ensembl ID

• ENST00000318473
• ENSP00000324444
• ENSG00000151332
• ENST00000359527
• ENSP00000352517
• ENST00000416007
• ENSP00000399718

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.7
histone modification site profile	0.7
biological process	0.67
tissue	0.63
tissue sample	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.33   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 125   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.33   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0