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Tbio
TOMM22
Mitochondrial import receptor subunit TOM22 homolog

Protein Summary
Description
Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore. The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216034
  • ENSP00000216034
  • ENSG00000100216

Symbol
  • TOM22
  • 1C9-2
  • TOM22
  • MST065
  • MSTP065
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
transcription factor binding site profile
0.74
drug perturbation
0.71
cellular component
0.7
interacting protein
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.61   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.61   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (155)
MFN1
Tbio
Novelty:  0.00372574
p_int:  0.999978244
p_ni:  0.000021756
Score:  0.853
Data Source:  BioPlex,STRINGDB
TOMM40
Tbio
Novelty:  0.0041507
p_int:  0.999943778
p_ni:  0.000056222
Score:  0.997
Data Source:  BioPlex,STRINGDB
SEC11C
Tdark
Family:  Enzyme
Novelty:  0.19577003
p_int:  0.99975145
p_ni:  0.000246953
p_wrong:  0.000001597
Score:  0.196
Data Source:  BioPlex,STRINGDB
TOMM40L
Tdark
Novelty:  0.24691216
p_int:  0.999646298
p_wrong:  0.000353702
Score:  0.921
Data Source:  BioPlex,STRINGDB
MTG2
Tbio
Family:  Enzyme
Novelty:  0.06104792
p_int:  0.992468773
p_ni:  0.007349146
p_wrong:  0.000182081
Score:  0.152
Data Source:  BioPlex,STRINGDB
SFXN3
Tbio
Novelty:  0.18698456
p_int:  0.980692033
p_ni:  0.016053449
p_wrong:  0.003254517
Score:  0.386
Data Source:  BioPlex,STRINGDB
SLC35B2
Tbio
Family:  Transporter
Novelty:  0.01516638
p_int:  0.973344539
p_ni:  0.02665545
p_wrong:  1.1e-8
Data Source:  BioPlex
DDX11
Tbio
Family:  Enzyme
Novelty:  0.02282234
p_int:  0.970033423
p_ni:  0.029041296
p_wrong:  0.000925281
Data Source:  BioPlex
SLC25A24
Tbio
Family:  Transporter
Novelty:  0.06151955
p_int:  0.954990026
p_ni:  0.045009641
p_wrong:  3.33e-7
Data Source:  BioPlex
STK39
Tchem
Family:  Kinase
Novelty:  0.00548476
p_int:  0.930217635
p_ni:  0.069773588
p_wrong:  0.000008777
Score:  0.185
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Reactome
Mitochondrial protein import
Reactome
Mitophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Mitochondrial protein import
Mitophagy
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
5
4
5
97.9
heel bone mineral density
3
4
5
95.9
1
1
0
1.2
79.5
serum gamma-glutamyl transferase measurement
2
1
2
72.9
mathematical ability
3
2
3
67.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
5
97.9
heel bone mineral density
5
95.9
0
1.2
79.5
serum gamma-glutamyl transferase measurement
2
72.9
mathematical ability
3
67.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
translocase of outer mitochondrial membrane 22
VGNC:8866
743431
Macaque
translocase of outer mitochondrial membrane 22
701286
Mouse
MGI:2450248
223696
Rat
RGD:1303260
300075
Dog
translocase of outer mitochondrial membrane 22
610117
Species
Name
OMA
EggNOG
Inparanoid
Chimp
translocase of outer mitochondrial membrane 22
Macaque
translocase of outer mitochondrial membrane 22
Mouse
Rat
Dog
translocase of outer mitochondrial membrane 22
Publication Statistics
PubMed Score 85.61
PubMed score by year
PubTator Score 29.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title