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Tbio
TNFRSF19
Tumor necrosis factor receptor superfamily member 19

Protein Summary
Description
Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248484
  • ENSP00000248484
  • ENSG00000127863
  • ENST00000382258
  • ENSP00000371693
  • ENST00000382263
  • ENSP00000371698
  • ENST00000403372
  • ENSP00000385408

Symbol
  • TAJ
  • TROY
  • TAJ
  • TROY
  • TRADE
  • TAJ-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.94
transcription factor perturbation
0.88
transcription factor
0.85
microRNA
0.82
small molecule perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.13   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 314   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.13   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (78)
1 – 10 of 78
CST2
Tbio
Novelty: 0.03317401
p_int: 0.999811163
p_ni: 0.000179431
p_wrong: 0.000009406
Data Source: BioPlex
TYK2
Tclin
Family: Kinase
Novelty: 0.00331363
p_int: 0.999703849
p_ni: 0.00029615
p_wrong: 1e-9
Data Source: BioPlex
KLK10
Tbio
Family: Enzyme
Novelty: 0.01327825
p_int: 0.999660545
p_ni: 0.000202602
p_wrong: 0.000136853
Data Source: BioPlex
ZNF101
Tdark
Family: TF
Novelty: 0.5
p_int: 0.999657828
p_ni: 0.000276398
p_wrong: 0.000065774
Score: 0.183
Data Source: BioPlex,STRINGDB
CALML5
Tbio
Novelty: 0.03997456
p_int: 0.999583876
p_ni: 0.000416124
Data Source: BioPlex
AMY1A
Tchem
Family: Enzyme
Novelty: 0.00383591
p_int: 0.999300825
p_ni: 0.000699175
Data Source: BioPlex
CRNN
Tbio
Novelty: 0.02535031
p_int: 0.999264311
p_ni: 0.000735689
Data Source: BioPlex
FLG
Tbio
Novelty: 0.0009107
p_int: 0.998186294
p_ni: 0.001813706
Data Source: BioPlex
CST1
Tbio
Novelty: 0.02481888
p_int: 0.997439055
p_ni: 0.000495852
p_wrong: 0.002065093
Data Source: BioPlex
PHLDB3
Tdark
Novelty: 4
p_int: 0.997283202
p_ni: 0.002716798
Data Source: BioPlex
Publication Statistics
PubMed Score  45.13

PubMed score by year
PubTator Score  170.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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