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Tbio
GPR27
Probable G-protein coupled receptor 27

Protein Summary
Description
Orphan receptor. Possible candidate for amine-like G-protein coupled receptor. GPR27 is a member of the G protein-coupled receptors (GPCRs), a large family of receptors that have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli such as neurotransmitters, hormones, or light induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins.[supplied by OMIM, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304411
  • ENSP00000303149
  • ENSG00000170837

Symbol
  • SREB1
  • SREB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.74
histone modification site profile
0.66
small molecule perturbation
0.64
tissue sample
0.6
PubMedID
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.65   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.65   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (140)
GPR25
Tdark
Family:  GPCR
Novelty:  0.42142701
Score:  0.951
Data Source:  STRINGDB
GPR20
Tdark
Family:  GPCR
Novelty:  0.34435286
Score:  0.951
Data Source:  STRINGDB
GPR45
Tbio
Family:  GPCR
Novelty:  0.08366919
Score:  0.943
Data Source:  STRINGDB
GPR150
Tdark
Family:  GPCR
Novelty:  0.91287003
Score:  0.941
Data Source:  STRINGDB
GPR176
Tdark
Family:  GPCR
Novelty:  0.28180289
Score:  0.939
Data Source:  STRINGDB
GPR15
Tbio
Family:  GPCR
Novelty:  0.00673057
Score:  0.934
Data Source:  STRINGDB
PTGIR
Tclin
Family:  GPCR
Novelty:  0.0091906
Score:  0.933
Data Source:  STRINGDB
GPR84
Tchem
Family:  GPCR
Novelty:  0.02360587
Score:  0.928
Data Source:  STRINGDB
ADCY5
Tchem
Family:  Enzyme
Novelty:  0.00307839
Score:  0.925
Data Source:  STRINGDB
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
Score:  0.925
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
2
3
87.5
monocyte count
2
2
2
77.6
mosaic loss of chromosome Y measurement
2
1
2
76.5
granulocyte percentage of myeloid white cells
1
1
1
50.6
apolipoprotein A 1 measurement
1
1
1
45.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
3
87.5
monocyte count
2
77.6
mosaic loss of chromosome Y measurement
2
76.5
granulocyte percentage of myeloid white cells
1
50.6
apolipoprotein A 1 measurement
1
45.7
Find similar targets by:
IDG Resources
Genetic Construct
GPR27-Tango
image for GPR27-Tango
Details:
  • Vector:  addgene66349
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR27-Tango
Order Genetic Construct from:
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1202299
14761
Rat
RGD:71067
65275
Opossum
G protein-coupled receptor 27 [Source:HGNC Symbol;Acc:HGNC:4482]
Platypus
G protein-coupled receptor 27
100086052
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Opossum
G protein-coupled receptor 27 [Source:HGNC Symbol;Acc:HGNC:4482]
Platypus
G protein-coupled receptor 27
Publication Statistics
PubMed Score 6.65
PubMed score by year
PubTator Score 4.01
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title