You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RPRM
Protein reprimo

Protein Summary
Description
May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325926
  • ENSP00000314946
  • ENSG00000177519

Symbol
  • REPRIMO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.79
gene perturbation
0.73
PubMedID
0.73
small molecule perturbation
0.69
histone modification site profile
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.12   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.12   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
3.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
3.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
reprimo, TP53 dependent G2 arrest mediator homolog
VGNC:14432
736900
Macaque
reprimo, TP53 dependent G2 arrest mediator homolog
696097
Mouse
MGI:1915124
67874
Rat
RGD:1595512
680110
Horse
reprimo, TP53 dependent G2 arrest mediator homolog
VGNC:22544
100058360
Species
Name
OMA
EggNOG
Inparanoid
Chimp
reprimo, TP53 dependent G2 arrest mediator homolog
Macaque
reprimo, TP53 dependent G2 arrest mediator homolog
Mouse
Rat
Horse
reprimo, TP53 dependent G2 arrest mediator homolog
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NS64-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (43)
1 – 10 of 43
ADCY9
Tbio
Family:  Enzyme
Novelty:  0.00744116
p_int:  0.999578935
p_ni:  0.000421062
p_wrong:  2e-9
Data Source:  BioPlex
TMEM214
Tdark
Novelty:  0.32604613
p_int:  0.99932491
p_ni:  0.00067509
Data Source:  BioPlex
UGT8
Tbio
Family:  Enzyme
Novelty:  0.02518383
p_int:  0.983784834
p_ni:  0.016215166
Data Source:  BioPlex
STEAP3
Tbio
Family:  Enzyme
Novelty:  0.02042104
p_int:  0.977242173
p_ni:  0.022711265
p_wrong:  0.000046562
Score:  0.401
Data Source:  BioPlex,STRINGDB
DPY19L4
Tdark
Family:  Enzyme
Novelty:  0.99997412
p_int:  0.97654387
p_ni:  0.023126037
p_wrong:  0.000330093
Data Source:  BioPlex
CERK
Tchem
Family:  Kinase
Novelty:  0.0103948
p_int:  0.953833764
p_ni:  0.034169276
p_wrong:  0.011996961
Data Source:  BioPlex
WLS
Tbio
Novelty:  0.01459149
p_int:  0.941096543
p_ni:  0.058903458
Data Source:  BioPlex
BMPR1A
Tchem
Family:  Kinase
Novelty:  0.00343928
p_int:  0.899541759
p_ni:  0.052798638
p_wrong:  0.047659603
Data Source:  BioPlex
IPO11
Tbio
Novelty:  0.09553616
p_int:  0.885621926
p_ni:  0.114378074
Data Source:  BioPlex
SLC19A2
Tbio
Family:  Transporter
Novelty:  0.00761796
p_int:  0.874867651
p_ni:  0.125129338
p_wrong:  0.000003011
Data Source:  BioPlex
Publication Statistics
PubMed Score  40.12

PubMed score by year
PubTator Score  25.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer