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Tbio
THSD1
Thrombospondin type-1 domain-containing protein 1

Protein Summary
Description
The protein encoded by this gene contains a type 1 thrombospondin domain, which is found in a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258613
  • ENSP00000258613
  • ENSG00000136114
  • ENST00000349258
  • ENSP00000340650
  • ENST00000648254
  • ENSP00000497520

Symbol
  • TMTSP
  • TMTSP
  • UNQ3010
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
kinase perturbation
0.71
tissue sample
0.62
PubMedID
0.57
protein complex
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.46   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.46   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (8)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Metabolism of proteins
Gene Ontology Terms (3)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (53)
1 – 10 of 53
THSD4
Tbio
Novelty: 0.16828393
Score: 0.925
Data Source: STRINGDB
SPON2
Tbio
Novelty: 0.01723508
Score: 0.92
Data Source: STRINGDB
THBS1
Tbio
Novelty: 0.00083403
Score: 0.919
Data Source: STRINGDB
ADAMTSL3
Tbio
Novelty: 0.10202493
Score: 0.916
Data Source: STRINGDB
THBS2
Tbio
Novelty: 0.00401454
Score: 0.914
Data Source: STRINGDB
ADAMTS5
Tchem
Family: Enzyme
Novelty: 0.00480382
Score: 0.911
Data Source: STRINGDB
ADAMTSL1
Tbio
Novelty: 0.09459214
Score: 0.909
Data Source: STRINGDB
ADAMTSL4
Tbio
Novelty: 0.04959452
Score: 0.907
Data Source: STRINGDB
SPON1
Tbio
Novelty: 0.00388947
Score: 0.904
Data Source: STRINGDB
CFP
Tbio
Novelty: 0.00062861
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.46

PubMed score by year
PubTator Score  7.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer