Tbio KCNIP2 Kv channel-interacting protein 2

Protein Summary

Description

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity). This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NS61
• A6NJE5
• A8MQ75
• Q3YAC6
• Q3YAC8
• Q3YAC9
• Q7Z6F1
• Q96K86
• Q96T41
• Q96T42
• Q96T43
• Q96T44
• Q9H0N4
• Q9HD10
• Q9HD11
• Q9NS60
• Q9NY10
• Q9NZI1
• KChIP2

Gene Name

• KCNIP2

Ensembl ID

• ENST00000239117
• ENSP00000239117
• ENSG00000120049
• ENST00000343195
• ENSP00000344169
• ENST00000348850
• ENSP00000239118
• ENST00000353068
• ENSP00000341624
• ENST00000356640
• ENSP00000349055
• ENST00000358038
• ENSP00000350733
• ENST00000434163
• ENSP00000411679
• ENST00000461105
• ENSP00000420040

Symbol

• KCHIP2
• KCHIP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
kinase perturbation	0.84
protein domain	0.73
virus perturbation	0.72
gene perturbation	0.65

Protein Classes

DTO Classes

Protein / Ion Channel / Kv Channel-interacting Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.18   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 384   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.18   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 384   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0