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Tbio
TOPORS
E3 ubiquitin-protein ligase Topors

Protein Summary
Description
Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360538
  • ENSP00000353735
  • ENSG00000197579
  • ENST00000379858
  • ENSP00000369187

Symbol
  • LUN
  • TP53BPL
  • LUN
  • RP31
  • P53BP3
  • TP53BPL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.96
biological process
0.95
transcription factor binding site profile
0.82
hub protein
0.79
molecular function
0.79


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.6   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.6   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (121)
UBE2D1
Tbio
Novelty:  0.00865867
p_int:  0.999997826
p_ni:  0.000002174
Score:  0.559
Data Source:  BioPlex,STRINGDB
LLGL2
Tbio
Novelty:  0.07084531
p_int:  0.999946192
p_ni:  0.000053808
Data Source:  BioPlex
ZC3H18
Tdark
Novelty:  0.3515546
p_int:  0.99992415
p_ni:  0.000075822
p_wrong:  2.8e-8
Score:  0.257
Data Source:  BioPlex,STRINGDB
SPIN1
Tchem
Novelty:  0.00889909
p_int:  0.999901912
p_ni:  0.000098086
p_wrong:  2e-9
Score:  0.738
Data Source:  BioPlex,STRINGDB
UBE2E3
Tbio
Novelty:  0.03477232
p_int:  0.999553497
p_ni:  0.000446502
Score:  0.191
Data Source:  BioPlex,STRINGDB
ZNF786
Tdark
Family:  TF
Novelty:  10.67468525
p_int:  0.999013643
p_ni:  0.000986333
p_wrong:  2.4e-8
Score:  0.204
Data Source:  BioPlex,STRINGDB
UBE2W
Tbio
Novelty:  0.07255713
p_int:  0.998920003
p_ni:  0.001079996
p_wrong:  1e-9
Data Source:  BioPlex
ZNF214
Tbio
Family:  TF
Novelty:  0.15323721
p_int:  0.997948034
p_ni:  0.002051965
Score:  0.554
Data Source:  BioPlex,STRINGDB
ZNF324B
Tdark
Family:  TF
Novelty:  1.89922228
p_int:  0.997608064
p_ni:  0.002391919
p_wrong:  1.7e-8
Data Source:  BioPlex
ZNF263
Tbio
Family:  TF
Novelty:  0.098799
p_int:  0.997388259
p_ni:  0.002611737
p_wrong:  4e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Metabolism of proteins (R-HSA-392499)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
SUMO E3 ligases SUMOylate target proteins
Reactome
SUMOylation
Reactome
SUMOylation of SUMOylation proteins
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
SUMO E3 ligases SUMOylate target proteins
SUMOylation
SUMOylation of SUMOylation proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (38)
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Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
83
hemoglobin measurement
2
2
2
80.9
red blood cell density measurement
1
1
1
78.1
erythrocyte count
1
1
1
13.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
83
hemoglobin measurement
2
80.9
red blood cell density measurement
1
78.1
erythrocyte count
1
13.3
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TOP1 binding arginine/serine rich protein
VGNC:10123
744660
Macaque
TOP1 binding arginine/serine rich protein
703930
Mouse
MGI:2146189
106021
Rat
RGD:1305270
362501
Dog
TOP1 binding arginine/serine rich protein
VGNC:47712
481577
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TOP1 binding arginine/serine rich protein
Macaque
TOP1 binding arginine/serine rich protein
Mouse
Rat
Dog
TOP1 binding arginine/serine rich protein
Publication Statistics
PubMed Score 26.60
PubMed score by year
PubTator Score 143.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title