Tbio CREBZF CREB/ATF bZIP transcription factor

Protein Summary

Description

Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells.

Uniprot Accession IDs

• Q9NS37
• B2R8Q9
• Q0P5U9
• Q52LT3

Gene Name

• CREBZF

Ensembl ID

• ENST00000490820
• ENSP00000434281
• ENSG00000137504
• ENST00000527447
• ENSP00000433459

Symbol

• ZF
• ZF
• SMILE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
disease perturbation	0.9
microRNA	0.86
transcription factor binding site profile	0.77
tissue sample	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.47   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 187   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.47   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0