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Tbio
RGS18
Regulator of G-protein signaling 18

Protein Summary
Description
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha. This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367460
  • ENSP00000356430
  • ENSG00000150681

Symbol
  • RGS13
  • RGS13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.78
tissue sample
0.76
tissue
0.54
gene perturbation
0.47
phenotype
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.5   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 175   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.5   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (14)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
G alpha (q) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (99)
1 – 10 of 99
GNAI1
Tbio
Novelty: 0.0488971
Score: 0.971
Data Source: STRINGDB
GNAQ
Tbio
Novelty: 0.0008997
Score: 0.965
Data Source: STRINGDB
GNAI2
Tbio
Novelty: 0.03014729
Score: 0.962
Data Source: STRINGDB
GNAI3
Tbio
Novelty: 0.03484857
Score: 0.96
Data Source: STRINGDB
GNAT3
Tbio
Novelty: 0.00702357
Score: 0.952
Data Source: STRINGDB
GNA15
Tbio
Novelty: 0.00159196
Score: 0.934
Data Source: STRINGDB
GNA14
Tbio
Novelty: 0.0587776
Score: 0.926
Data Source: STRINGDB
GNA11
Tbio
Novelty: 0.00128664
Score: 0.926
Data Source: STRINGDB
PLEK
Tbio
Novelty: 0.00074263
Score: 0.719
Data Source: STRINGDB
PTPRC
Tchem
Family: Enzyme
Novelty: 0.00012027
Score: 0.678
Data Source: STRINGDB
Publication Statistics
PubMed Score  26.50

PubMed score by year
PubTator Score  10.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer