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Tbio
RASSF1
Ras association domain-containing protein 1

Protein Summary
Description
Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. This gene encodes a protein si ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327761
  • ENSP00000333327
  • ENSG00000068028
  • ENST00000357043
  • ENSP00000349547
  • ENST00000359365
  • ENSP00000352323
  • ENST00000395117
  • ENSP00000378549
  • ENST00000395126
  • ENSP00000378558
  • ENST00000482447
  • ENSP00000433000
  • ENST00000616212
  • ENSP00000482696

Symbol
  • RDA32
  • 123F2
  • RDA32
  • NORE2A
  • RASSF1A
  • REH3P21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.95
co-expressed gene
0.93
virus perturbation
0.88
biological term
0.86
hub protein
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 692.41   (req: < 5)
Gene RIFs: 396   (req: <= 3)
Antibodies: 466   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 692.41   (req: >= 5)
Gene RIFs: 396   (req: > 3)
Antibodies: 466   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (77)
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Non-small cell lung cancer
KEGG
Bladder cancer
KEGG
Hippo signaling pathway
KEGG
Hippo signaling pathway - multiple species
KEGG
Ras signaling pathway
Name
Explore in Pharos
Explore in Source
Non-small cell lung cancer
Bladder cancer
Hippo signaling pathway
Hippo signaling pathway - multiple species
Ras signaling pathway
Protein-Protein Interactions (164)
1 – 10 of 164
VAPB
Tbio
Novelty: 0.00566042
p_int: 0.999999976
p_ni: 2e-8
p_wrong: 4e-9
Score: 0.181
Data Source: BioPlex,STRINGDB
VAPA
Tbio
Novelty: 0.0022428
p_int: 0.999999631
p_ni: 3.36e-7
p_wrong: 3.2e-8
Score: 0.252
Data Source: BioPlex,STRINGDB
STK4
Tchem
Family: Kinase
Novelty: 0.02467485
p_int: 0.999999112
p_ni: 8.88e-7
Score: 0.995
Data Source: BioPlex,STRINGDB
STK3
Tchem
Family: Kinase
Novelty: 0.09293063
p_int: 0.999998447
p_ni: 0.000001553
Score: 0.985
Data Source: BioPlex,STRINGDB
BTRC
Tbio
Novelty: 0.00393331
p_int: 0.999998064
p_ni: 0.000001767
p_wrong: 1.68e-7
Score: 0.665
Data Source: BioPlex,STRINGDB
MAP1S
Tbio
Novelty: 0.03122174
p_int: 0.999997782
p_ni: 0.000002218
Score: 0.829
Data Source: BioPlex,STRINGDB
SNX27
Tbio
Novelty: 0.02796021
p_int: 0.999939846
p_ni: 0.000060154
Score: 0.306
Data Source: BioPlex,STRINGDB
MTHFR
Tbio
Family: Enzyme
Novelty: 0.00020963
p_int: 0.999918691
p_ni: 0.000081309
Score: 0.408
Data Source: BioPlex,STRINGDB
MAP1B
Tchem
Novelty: 0.00233868
p_int: 0.999743557
p_ni: 0.000256443
p_wrong: 1e-9
Score: 0.493
Data Source: BioPlex,STRINGDB
ITPRIP
Tdark
Novelty: 0.31547929
p_int: 0.995818444
p_ni: 0.004181556
Score: 0.228
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  692.41

PubMed score by year
PubTator Score  706.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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