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Tbio
HELLS
Lymphoid-specific helicase

Protein Summary
Description
Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348459
  • ENSP00000239027
  • ENSG00000119969
  • ENST00000394045
  • ENSP00000377609

Symbol
  • PASG
  • SMARCA6
  • LSH
  • ICF4
  • PASG
  • SMARCA6
  • Nbla10143
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
PubMedID
0.96
molecular function
0.94
protein complex
0.94
kinase perturbation
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.36   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.36   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
5
5
96.4
neutrophil count
2
2
2
85.8
serum metabolite measurement
1
1
1
77.6
myeloid white cell count
1
1
1
76.5
appendicular lean mass
1
2
2
66.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
5
96.4
neutrophil count
2
85.8
serum metabolite measurement
1
77.6
myeloid white cell count
1
76.5
appendicular lean mass
2
66.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
helicase, lymphoid specific
450624
Macaque
helicase, lymphoid specific
701598
Mouse
MGI:106209
15201
Rat
RGD:1309820
294071
Dog
helicase, lymphoid specific
VGNC:41649
486809
Species
Name
OMA
EggNOG
Inparanoid
Chimp
helicase, lymphoid specific
Macaque
helicase, lymphoid specific
Mouse
Rat
Dog
helicase, lymphoid specific
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NRZ9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (88)
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Wnt signaling pathway
PathwayCommons: pid
Validated transcriptional targets of deltaNp63 isoforms
Name
Explore in Pharos
Explore in Source
Wnt signaling pathway
Validated transcriptional targets of deltaNp63 isoforms
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (237)
1 – 10 of 237
SEMA4C
Tbio
Novelty:  0.01237067
p_int:  0.999843049
p_ni:  0.000156951
Data Source:  BioPlex
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.999373749
p_ni:  0.000626251
Data Source:  BioPlex
LYPD3
Tbio
Novelty:  0.03248533
p_int:  0.997244022
p_ni:  0.002755978
Data Source:  BioPlex
LAMP2
Tbio
Novelty:  0.00168009
p_int:  0.997085999
p_ni:  0.002914001
Score:  0.214
Data Source:  BioPlex,STRINGDB
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
p_int:  0.969253157
p_ni:  0.030746843
Data Source:  BioPlex
FURIN
Tchem
Family:  Enzyme
Novelty:  0.00055079
p_int:  0.961070115
p_ni:  0.038929872
p_wrong:  1.3e-8
Data Source:  BioPlex
SLC39A9
Tbio
Family:  Transporter
Novelty:  0.06143625
p_int:  0.951176134
p_ni:  0.048823866
Data Source:  BioPlex
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.946061744
p_ni:  0.053938249
p_wrong:  6e-9
Data Source:  BioPlex
F9
Tchem
Family:  Enzyme
Novelty:  0.00032127
p_int:  0.9445318
p_ni:  0.0554682
Data Source:  BioPlex
RCBTB2
Tbio
Novelty:  0.04244536
p_int:  0.915788473
p_ni:  0.07610212
p_wrong:  0.008109407
Score:  0.377
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  93.36

PubMed score by year
PubTator Score  101.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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