Tbio HELLS Lymphoid-specific helicase

Protein Summary

Description

Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• Q9NRZ9
• B2RB41
• Q3LID1
• Q6I7N7
• Q76H76
• Q76H77
• Q76H78
• Q76H79
• Q76H80
• Q76H81
• Q7Z397
• Q7Z5X2
• Q8N6P4
• Q9H4P5

Gene Name

• HELLS

Ensembl ID

• ENST00000348459
• ENSP00000239027
• ENSG00000119969
• ENST00000394045
• ENSP00000377609

Symbol

• PASG
• SMARCA6
• LSH
• ICF4
• PASG
• SMARCA6
• Nbla10143

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.96
PubMedID	0.96
molecular function	0.94
protein complex	0.94
kinase perturbation	0.91

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.5   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 248   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.5   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0