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Tbio
AGPAT4
1-acyl-sn-glycerol-3-phosphate acyltransferase delta

Protein Summary
Description
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320285
  • ENSP00000314036
  • ENSG00000026652

Symbol
  • 1-AGPAT4
  • dJ473J16.2
  • LPAAT-delta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.76
trait
0.75
kinase perturbation
0.71
transcription factor binding site profile
0.71
transcription factor
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.16   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.16   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.99423632
p_ni:  0.00576368
Data Source:  BioPlex
SLC7A1
Tbio
Family:  Transporter
Novelty:  0.00197313
p_int:  0.984942784
p_ni:  0.015057215
p_wrong:  1e-9
Score:  0.168
Data Source:  BioPlex,STRINGDB
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
p_int:  0.974699328
p_ni:  0.025300672
Data Source:  BioPlex
CYB5A
Tbio
Novelty:  0.00047376
p_int:  0.952828701
p_ni:  0.047171297
p_wrong:  1e-9
Score:  0.289
Data Source:  BioPlex,STRINGDB
VIPR1
Tchem
Family:  GPCR
Novelty:  0.0016529
p_int:  0.855476547
p_ni:  0.144523453
Score:  0.161
Data Source:  BioPlex,STRINGDB
GPAT4
Tbio
Family:  Enzyme
Novelty:  0.03409111
Score:  0.963
Data Source:  STRINGDB
GPAM
Tbio
Family:  Enzyme
Novelty:  0.00973127
Score:  0.959
Data Source:  STRINGDB
GPAT3
Tbio
Family:  Enzyme
Novelty:  0.03251979
Score:  0.957
Data Source:  STRINGDB
GPAT2
Tbio
Family:  Enzyme
Novelty:  0.03807198
Score:  0.952
Data Source:  STRINGDB
MBOAT2
Tbio
Family:  Enzyme
Novelty:  0.01820899
Score:  0.946
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 3 of 3
DGAT1
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
LIPF
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
PNLIP
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
Pathways (18)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PA
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PA
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipoprotein A measurement
3
3
1
4.8
70.5
low density lipoprotein cholesterol measurement
1
1
1
64.9
apolipoprotein B measurement
1
1
1
64.4
total cholesterol measurement
1
1
1
54.4
apolipoprotein A 1 measurement
1
1
0
3
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipoprotein A measurement
1
4.8
70.5
low density lipoprotein cholesterol measurement
1
64.9
apolipoprotein B measurement
1
64.4
total cholesterol measurement
1
54.4
apolipoprotein A 1 measurement
0
3
26.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
1-acylglycerol-3-phosphate O-acyltransferase 4
VGNC:12571
741254
Macaque
1-acylglycerol-3-phosphate O-acyltransferase 4
704132
Mouse
MGI:1915512
68262
Rat
RGD:619916
170919
Dog
1-acylglycerol-3-phosphate O-acyltransferase 4
VGNC:37713
612306
Species
Name
OMA
EggNOG
Inparanoid
Chimp
1-acylglycerol-3-phosphate O-acyltransferase 4
Macaque
1-acylglycerol-3-phosphate O-acyltransferase 4
Mouse
Rat
Dog
1-acylglycerol-3-phosphate O-acyltransferase 4
Publication Statistics
PubMed Score 12.16
PubMed score by year
PubTator Score 3.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title